CAJ | 학술논문

目的：探讨慢性乙型肝炎（CHB）患者不同免疫状态下血清γ谷氨酰转肽酶（γ-GGT）水平与血清HBV DNA载量、ALT之间的关系。方法：收集191例处于不同免疫状态的CHB患者，包括非活动性HBV携带期（B 组，55例）、免疫耐受期（C 组，47例）、HBeAg 阴性 CHB（D 组，17例）、免疫活化期（E 组，72例）及61例健康对照（A组），检测各组患者血清γ-GGT 水平，同时检测血清 HBV DNA 载量及 ALT 水平。结果：D、E 组γ-GGT水平明显高于A、B、C组（P＜0．01）。相关性分析发现，D 组和 E 组γ-GGT 与血清 ALT、AST水平均呈正相关（ P ＜0．01），与 HBV DNA 载量无相关性。结论：不同免疫状态下 CHB 患者γ-GGT 水平不同，血清γ-GGT 水平升高可能是 CHB 患者进入免疫活化期的指标，肝脏炎症损伤是影响其水平的主要因素。
목적：탐토만성을형간염（CHB）환자불동면역상태하혈청γ곡안선전태매（γ-GGT）수평여혈청HBV DNA재량、ALT지간적관계。방법：수집191례처우불동면역상태적CHB환자，포괄비활동성HBV휴대기（B 조，55례）、면역내수기（C 조，47례）、HBeAg 음성 CHB（D 조，17례）、면역활화기（E 조，72례）급61례건강대조（A조），검측각조환자혈청γ-GGT 수평，동시검측혈청 HBV DNA 재량급 ALT 수평。결과：D、E 조γ-GGT수평명현고우A、B、C조（P＜0．01）。상관성분석발현，D 조화 E 조γ-GGT 여혈청 ALT、AST수평균정정상관（ P ＜0．01），여 HBV DNA 재량무상관성。결론：불동면역상태하 CHB 환자γ-GGT 수평불동，혈청γ-GGT 수평승고가능시 CHB 환자진입면역활화기적지표，간장염증손상시영향기수평적주요인소。
Objective To observe the serum γ-glutamyltransferase (γ-GGT) levels in patients with chronic hepatitis B virus (HBV) infection in different immune status and investigate their relationship with HBV DNA loads and ALT levels. Methods Blood samples were collected from 191 patients with chronic HBV infection in different immune status, including inactive HBV carrier state (group B,n = 55), immune tolerance phase (group C, n=47), HBeAg-negative CHB (group D, n =17), immune-reactive phase (group E, n=72) and 61 healthy individuals ( group A) for the detection of the serum γ-GGT, ALT level and HBV DNA loads. Results γ-GGT level were obviously higher in groups D and E than those in groups of A, B and C (P<0.01). Correlation analysis showed that the γ-GGT levels were positively correlated with serum ALT , AST levels in HBeAg-negative CHB and immune-reactive phase , but not correlated with HBV DNA loads. Conclusions The levels of γ-GGT are different during different immune status in patients with chronic HBV infection. The increased serum γ-GGT level may be an indicator for patients with chronic HBV infection entering immune active phase. The liver inflammation is the major impact factor to the γ-GGT levels.