中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
14期
2648-2652
,共5页
高血压%动脉硬化%血压正常高值%脉搏波传导速度%踝臂指数%颈动脉内膜中层厚度
高血壓%動脈硬化%血壓正常高值%脈搏波傳導速度%踝臂指數%頸動脈內膜中層厚度
고혈압%동맥경화%혈압정상고치%맥박파전도속도%과비지수%경동맥내막중층후도
Hypertension%Arteriosclerosis%High-normal blood pressure%Ankle-brachial index%Pulse wave velocity%Intima-media thickness
目的：利用无创方法探讨血压正常高值人群动脉血管功能和结构的变化。方法应用博时全自动动脉硬化检测系统及超声诊断仪对349例血压正常高值人群进行踝臂指数（ABI）、臂-踝脉搏波传导速度（baPWV）、颈动脉内膜中层厚度（IMT）的检测，并与同期受检的201例血压正常人群、303例原发性高血压1级患者及77例原发性高血压2级患者的检测结果进行对比研究。结果正常高值血压组受检人群脉搏波传导速度、颈动脉内膜中层厚度的异常检出率较正常血压组明显增高，而低于原发性高血压1、2级组，且正常高值血压组、原发性高血压1、2级组分别与正常血压组相比，差异均有统计学意义（P＜0.0083）；而踝臂指数异常的检出率均较低，正常血压组、正常高值血压组、原发性高血压1级组之间无统计学差异（P＞0.0083），但以上三组分别与原发性高血压2级组比较差异均有统计学意义（P＜0.0083）。结论血压正常高值人群尚未发展至高血压阶段时已经开始出现动脉血管功能和结构的损害，表现为血管顺应性下降，僵硬度增加，动脉内膜增厚，斑块形成，甚至出现管腔狭窄及堵塞等一系列病理改变。
目的：利用無創方法探討血壓正常高值人群動脈血管功能和結構的變化。方法應用博時全自動動脈硬化檢測繫統及超聲診斷儀對349例血壓正常高值人群進行踝臂指數（ABI）、臂-踝脈搏波傳導速度（baPWV）、頸動脈內膜中層厚度（IMT）的檢測，併與同期受檢的201例血壓正常人群、303例原髮性高血壓1級患者及77例原髮性高血壓2級患者的檢測結果進行對比研究。結果正常高值血壓組受檢人群脈搏波傳導速度、頸動脈內膜中層厚度的異常檢齣率較正常血壓組明顯增高，而低于原髮性高血壓1、2級組，且正常高值血壓組、原髮性高血壓1、2級組分彆與正常血壓組相比，差異均有統計學意義（P＜0.0083）；而踝臂指數異常的檢齣率均較低，正常血壓組、正常高值血壓組、原髮性高血壓1級組之間無統計學差異（P＞0.0083），但以上三組分彆與原髮性高血壓2級組比較差異均有統計學意義（P＜0.0083）。結論血壓正常高值人群尚未髮展至高血壓階段時已經開始齣現動脈血管功能和結構的損害，錶現為血管順應性下降，僵硬度增加，動脈內膜增厚，斑塊形成，甚至齣現管腔狹窄及堵塞等一繫列病理改變。
목적：이용무창방법탐토혈압정상고치인군동맥혈관공능화결구적변화。방법응용박시전자동동맥경화검측계통급초성진단의대349례혈압정상고치인군진행과비지수（ABI）、비-과맥박파전도속도（baPWV）、경동맥내막중층후도（IMT）적검측，병여동기수검적201례혈압정상인군、303례원발성고혈압1급환자급77례원발성고혈압2급환자적검측결과진행대비연구。결과정상고치혈압조수검인군맥박파전도속도、경동맥내막중층후도적이상검출솔교정상혈압조명현증고，이저우원발성고혈압1、2급조，차정상고치혈압조、원발성고혈압1、2급조분별여정상혈압조상비，차이균유통계학의의（P＜0.0083）；이과비지수이상적검출솔균교저，정상혈압조、정상고치혈압조、원발성고혈압1급조지간무통계학차이（P＞0.0083），단이상삼조분별여원발성고혈압2급조비교차이균유통계학의의（P＜0.0083）。결론혈압정상고치인군상미발전지고혈압계단시이경개시출현동맥혈관공능화결구적손해，표현위혈관순응성하강，강경도증가，동맥내막증후，반괴형성，심지출현관강협착급도새등일계렬병리개변。
ObjectiveTo explore the artery elastic function and structure changes in high-normal blood pressure persons by non-invasive examination.MethodsThe Intima-media thickness (IMT) were detected, meanwhile, the Ankle-Brachial Index(ABI) and Pulse Wave Velocity (PWV) were measured in 349 prehypertensive people using Boso(BOSCH+SONH) automatic arteriosclerosis measurement system, and were compared with normotensive group(n=201), hypertension grade 1 group(n=303) and hypertension grade 2 group(n=77).Results The level of PWV and IMT in the high-normal blood pressure group were significantly higher than those of the normal blood pressure group and lower than hypertension grade 1 and 2 groups, and the difference between the three groups and normal blood pressure group were all significant(allP<0.008 3). While, the unnormal ratio of ABI were all lower in the four groups, and there were no statistic difference between every two groups during the normal blood pressure group,the high-normal blood pressure group and the hypertension grade 1 group, but the difference between the three groups and hypertension grade 2 group were all significant(allP<0.008 3). Conclusion The artery elastic function and structure changes already existed in high-normal blood pressure persons, which were characterized by the arterial stiffness increased, elasticity decreased, the intima-media thickened and thrombus, even(so much as) the arterial cavity narrow and blocked.
