中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
14期
2602-2607
,共6页
陈康%努尔兰·阿汗%马金山
陳康%努爾蘭·阿汗%馬金山
진강%노이란·아한%마금산
硬币病变,肺%危险因素%回归分析
硬幣病變,肺%危險因素%迴歸分析
경폐병변,폐%위험인소%회귀분석
Coin lesion,pulmonary%Risk factors%Regression analysis
目的：探讨影响孤立性肺结节良、恶性判断的危险因素。方法回顾性分析2004年1月至2013年12月经手术切除并经病理明确诊断孤立性肺结节的189例患者的资料。对以下资料：（1）年龄、性别、民族、吸烟史及吸烟量、临床症状、既往肿瘤史、肿瘤家族史；（2）实验室检查结果：血清CEA、血清肿瘤特异性生长因子（TSGF）、C-反应蛋白、红细胞沉降率；（3）影像学检查资料：肿瘤最大径、有无钙化、毛刺、分叶、胸膜凹陷征、CT 强化峰值、PET-SUV 值，先进行单因素分析，有统计学意义的再进行多因素 Logistic 回归分析。结果术后病理证实良性病变71例，恶性病变118例（62.43%），单因素分析显示，患者年龄、吸烟量、病变直径、钙化、毛刺、胸膜凹陷征、CT强化峰值、PET-SUV值、血清CEA、血清TSGF在良、恶性病变中的差异有统计学意义。多因素Logistic回归分析结果发现孤立性肺结节的危险因素有：患者年龄、病变大小、钙化、CT强化峰HU值、血清CEA及血清TSGF。结论患者年龄、血清CEA、血清TSGF、肿瘤最大径、伴有钙化、CT强化峰值，对判断肺结节的良、恶性有显著意义。
目的：探討影響孤立性肺結節良、噁性判斷的危險因素。方法迴顧性分析2004年1月至2013年12月經手術切除併經病理明確診斷孤立性肺結節的189例患者的資料。對以下資料：（1）年齡、性彆、民族、吸煙史及吸煙量、臨床癥狀、既往腫瘤史、腫瘤傢族史；（2）實驗室檢查結果：血清CEA、血清腫瘤特異性生長因子（TSGF）、C-反應蛋白、紅細胞沉降率；（3）影像學檢查資料：腫瘤最大徑、有無鈣化、毛刺、分葉、胸膜凹陷徵、CT 彊化峰值、PET-SUV 值，先進行單因素分析，有統計學意義的再進行多因素 Logistic 迴歸分析。結果術後病理證實良性病變71例，噁性病變118例（62.43%），單因素分析顯示，患者年齡、吸煙量、病變直徑、鈣化、毛刺、胸膜凹陷徵、CT彊化峰值、PET-SUV值、血清CEA、血清TSGF在良、噁性病變中的差異有統計學意義。多因素Logistic迴歸分析結果髮現孤立性肺結節的危險因素有：患者年齡、病變大小、鈣化、CT彊化峰HU值、血清CEA及血清TSGF。結論患者年齡、血清CEA、血清TSGF、腫瘤最大徑、伴有鈣化、CT彊化峰值，對判斷肺結節的良、噁性有顯著意義。
목적：탐토영향고립성폐결절량、악성판단적위험인소。방법회고성분석2004년1월지2013년12월경수술절제병경병리명학진단고립성폐결절적189례환자적자료。대이하자료：（1）년령、성별、민족、흡연사급흡연량、림상증상、기왕종류사、종류가족사；（2）실험실검사결과：혈청CEA、혈청종류특이성생장인자（TSGF）、C-반응단백、홍세포침강솔；（3）영상학검사자료：종류최대경、유무개화、모자、분협、흉막요함정、CT 강화봉치、PET-SUV 치，선진행단인소분석，유통계학의의적재진행다인소 Logistic 회귀분석。결과술후병리증실량성병변71례，악성병변118례（62.43%），단인소분석현시，환자년령、흡연량、병변직경、개화、모자、흉막요함정、CT강화봉치、PET-SUV치、혈청CEA、혈청TSGF재량、악성병변중적차이유통계학의의。다인소Logistic회귀분석결과발현고립성폐결절적위험인소유：환자년령、병변대소、개화、CT강화봉HU치、혈청CEA급혈청TSGF。결론환자년령、혈청CEA、혈청TSGF、종류최대경、반유개화、CT강화봉치，대판단폐결절적량、악성유현저의의。
ObjectiveTo review the risk factors affecting the definite pathological diagnosis of solitary pulmonary nodules(SPN).MethodsA retrospective study was conducted in 189 patients got definite pathological diagnosis of solitary pulmonary nodules from January 2004 to December 2013.The following factors were evaluated: age, gender, nation, history and quantity of smoking, symptoms, history of tumor, family history of tumor, serum CEA, serum TSGF, C-reactive protein, ESR, diameter, calcification, spicular sign, border, lobulated, the enhanced CT peak value, PET-SUV. Single factor analysis and multivariate logistic regrossion analysis were used to find the risk factors affecting the definite pathological diagnosis of solitary pulmonary nodules.ResultsPathologic exam showed that there were 71 benign lesions, 118 malignant lesions(62.43%). Single factor analysis showed that there were significant differences in age, smoking, diameter, calcification, burr, pleural indentation, the enhanced CT peak value, PET-SUV, serum CEA, serum TSGF between benign and malignant lesions. Further multivariate logistic regression analysis showed that age, serum CEA, serum TSGF, diameter, calcification, the enhanced CT peak value are the risk factors in judgement character of SPN.ConclusionAge,serum CEA, serum TSGF of patient and the diameter, calcification, the enhanced CT peak value of tumor are significant risk factors in judgment character of SPN.
