CAJ | 학술논문

目的：评价不同大小聚乙烯醇（PVA）颗粒在子宫腺肌症介入治疗中的临床疗效。方法回顾性分析152例经子宫动脉栓塞术治疗的子宫腺肌症患者，根据PVA颗粒的大小随机分为A（350～500μm）、B（500～710μm）两组，每组病例76例，比较两组病例经子宫动脉栓塞术治疗后临床症状缓解程度及术后不良反应的差异。结果在痛经减轻、子宫体积变化方面两组比较，术后3个月差异有统计学意义（P＜0.05），术后6个月两组比较无统计学差异（P＞0.05），术后1年两组痛经减轻程度有统计学差异（P＜0.05），而子宫体积方面两组比较无统计学差异（P＞0.05），1年后两组病例完全缓解率均达到80%以上，无统计学差异，术后不良反应两组比较有统计学差异（P＜0.05），A 组不良反应更为显著，而两组在月经期及月经量改变、总有效率比较无统计学差异（P＞0.05）。结论虽然两组临床效果半年后即达到相似，但A组术后不良反应疼痛更为严重，故从中长期效果及安全性来看，B组似乎更占优势。
목적：평개불동대소취을희순（PVA）과립재자궁선기증개입치료중적림상료효。방법회고성분석152례경자궁동맥전새술치료적자궁선기증환자，근거PVA과립적대소수궤분위A（350～500μm）、B（500～710μm）량조，매조병례76례，비교량조병례경자궁동맥전새술치료후림상증상완해정도급술후불량반응적차이。결과재통경감경、자궁체적변화방면량조비교，술후3개월차이유통계학의의（P＜0.05），술후6개월량조비교무통계학차이（P＞0.05），술후1년량조통경감경정도유통계학차이（P＜0.05），이자궁체적방면량조비교무통계학차이（P＞0.05），1년후량조병례완전완해솔균체도80%이상，무통계학차이，술후불량반응량조비교유통계학차이（P＜0.05），A 조불량반응경위현저，이량조재월경기급월경량개변、총유효솔비교무통계학차이（P＞0.05）。결론수연량조림상효과반년후즉체도상사，단A조술후불량반응동통경위엄중，고종중장기효과급안전성래간，B조사호경점우세。
ObjectiveTo evaluate whether different polyvinyl alcohol(PVA) particle sizes change the clinical outcome of uterine artery embolization(UAE) in adenomyosis.MethodsThis retrospective analysis study comprised 152 patients with adenomyosis undergoing UAE with PVA particles. In 76 patients in group A, UAE was started with 350-500μm particles, in 76 patients in group B, UAE was started with 500-710μm particles, the clinical outcome were evaluated between the two groups.Results At three months, there were statistically significant differences in decrease in size of uterus and the relieve of dysmenorrhea, however, there were no statistically significant differences in those facets, and there were also no statistically significant difference in the clinical outcome between the two groups after 1 year. But in group A adverse reactions after surgery were more serious, and what’s more, there were also no statistically significant differences between the menstrual period,the menstrual flow and the total effective rate. ConclusionsThe initial use of PVA particle sizes 350-500μm is associated with a higher mean pain score after UAE, although the outcome at 6 months is similar compared with the initial use of particle sizes 500-710μm. Therefore, from the long-term efficacy and safety point of view, group B(500-710μm) seems to be more dominant.