中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
14期
2566-2569
,共4页
糖尿病足%老年人%非手术
糖尿病足%老年人%非手術
당뇨병족%노년인%비수술
Diabetic foot%Aged%Non operation
目的：探讨复方多黏菌素B软膏在老年糖尿病足溃疡创面非手术修复中的应用。方法128例老年糖尿病足患者根据创面使用药物不同随机分为试验组（复方多黏菌素B组）及对照组（磺胺嘧啶银组），每组64例。分别在开始治疗后1、2、3、4周观察比较两组患者创面组织细菌定量、创面愈合率及表皮生长因子的表达。结果（1）在开始治疗后3周时试验组患者创面组织细菌定量均值小于对照组（P＜0.05），第4周后明显小于对照组（P＜0.01）；（2）两组患者创面愈合率在治疗1、2、3周后无统计学差异，4周后试验组创面愈合率明显高于对照组（P＜0.01）；（3）治疗3周后两组患者创面的表皮生长因子比较有统计学差异（P＜0.05），第4周差异更明显（P＜0.01）。结论复方多黏菌素B软膏适用于全身感染已被控制但局部感染较重、高龄、基础病变多、难以承受多次麻醉手术清创后植皮封闭创面的老年患者，对治疗修复糖尿病足溃疡创面是一种安全、有效、简易的外用药物。
目的：探討複方多黏菌素B軟膏在老年糖尿病足潰瘍創麵非手術脩複中的應用。方法128例老年糖尿病足患者根據創麵使用藥物不同隨機分為試驗組（複方多黏菌素B組）及對照組（磺胺嘧啶銀組），每組64例。分彆在開始治療後1、2、3、4週觀察比較兩組患者創麵組織細菌定量、創麵愈閤率及錶皮生長因子的錶達。結果（1）在開始治療後3週時試驗組患者創麵組織細菌定量均值小于對照組（P＜0.05），第4週後明顯小于對照組（P＜0.01）；（2）兩組患者創麵愈閤率在治療1、2、3週後無統計學差異，4週後試驗組創麵愈閤率明顯高于對照組（P＜0.01）；（3）治療3週後兩組患者創麵的錶皮生長因子比較有統計學差異（P＜0.05），第4週差異更明顯（P＜0.01）。結論複方多黏菌素B軟膏適用于全身感染已被控製但跼部感染較重、高齡、基礎病變多、難以承受多次痳醉手術清創後植皮封閉創麵的老年患者，對治療脩複糖尿病足潰瘍創麵是一種安全、有效、簡易的外用藥物。
목적：탐토복방다점균소B연고재노년당뇨병족궤양창면비수술수복중적응용。방법128례노년당뇨병족환자근거창면사용약물불동수궤분위시험조（복방다점균소B조）급대조조（광알밀정은조），매조64례。분별재개시치료후1、2、3、4주관찰비교량조환자창면조직세균정량、창면유합솔급표피생장인자적표체。결과（1）재개시치료후3주시시험조환자창면조직세균정량균치소우대조조（P＜0.05），제4주후명현소우대조조（P＜0.01）；（2）량조환자창면유합솔재치료1、2、3주후무통계학차이，4주후시험조창면유합솔명현고우대조조（P＜0.01）；（3）치료3주후량조환자창면적표피생장인자비교유통계학차이（P＜0.05），제4주차이경명현（P＜0.01）。결론복방다점균소B연고괄용우전신감염이피공제단국부감염교중、고령、기출병변다、난이승수다차마취수술청창후식피봉폐창면적노년환자，대치료수복당뇨병족궤양창면시일충안전、유효、간역적외용약물。
Objective To investigate the compound polymyxin B ointment application operation repair in non senile diabetic foot ulcers.Methods128 cases of elderly patients with diabetic foot wound using drugs according to different randomly divided into experimental group(compound compound nystatin group), and control group (silver sulfadiazine group), each group of 64 cases. In the expression of 1 weeks after treatment, 2 weeks, 3 weeks, 4 weeks were compared between the two groups of patients the wound tissue bacterial quantity, wound healing rate and the expression of epidermal growth factor. Results (1) In 3 weeks after the start of treatment when the patients in experimental group wound tissue bacterial quantity mean less than that of the control group (P<0.05), after fourth weeks was significantly less than the control group(P<0.01); (2) Two groups of patients the wound healing rate in the treatment of 1, 2, 3 weeks had no obvious difference, was significantly higher than that in control group, the experimental group was after 4 weeks of healing(P<0.01); (3) 3 weeks after the treatment, two patients with epidermal growth factor was statistically significant(P<0.05), fourth weeks had significant difference (P<0.01).Conclusions Compound nystatin B ointment applied to systemic infection has been controlled, but local infection is heavy, old base lesions, difficult to withstand repeated anesthesia operation after debridement and skin grafting wound closure in elderly patients. The compound multi nystatin ointment topical B is a safe, effective, easy to repair and treatment of diabetes foot ulcer.
