CAJ | 학술논문

目的：评价成人乙肝疫苗不同剂量和程序的安全性和免疫学效果。方法：按照自愿原则分别采用60、20、10μg乙肝疫苗和0、0-1-6、0-1-6免疫程序对成人乙肝易感者进行疫苗接种。三组间不良反应发生率及乙肝病毒表面抗原抗体（抗-HBs）阳转率等的比较采用χ2检验。结果：三组间不良反应发生率差异无统计学意义（χ2＝5．09，P＞0．05）。60μg乙肝疫苗组、20μg乙肝疫苗组和10μg乙肝疫苗组抗-HBs阳转率分别为96．7％、90．5％和88．1％，60μg乙肝疫苗组与20μg乙肝疫苗组间抗-HBs阳转率差异有统计学意义（χ2＝0．010，P＜0．017）；60μg乙肝疫苗组与10μg乙肝疫苗组间抗-HBs阳转率差异有统计学意义（χ2＝0．001，P＜0．017）。结论：60μg 乙肝疫苗具有与20μg乙肝疫苗、10μg乙肝疫苗同样的安全性，成人乙肝易感者接种60μg乙肝疫苗一针免疫效果优于20μg乙肝疫苗、10μg乙肝疫苗三针的免疫效果。
목적：평개성인을간역묘불동제량화정서적안전성화면역학효과。방법：안조자원원칙분별채용60、20、10μg을간역묘화0、0-1-6、0-1-6면역정서대성인을간역감자진행역묘접충。삼조간불량반응발생솔급을간병독표면항원항체（항-HBs）양전솔등적비교채용χ2검험。결과：삼조간불량반응발생솔차이무통계학의의（χ2＝5．09，P＞0．05）。60μg을간역묘조、20μg을간역묘조화10μg을간역묘조항-HBs양전솔분별위96．7％、90．5％화88．1％，60μg을간역묘조여20μg을간역묘조간항-HBs양전솔차이유통계학의의（χ2＝0．010，P＜0．017）；60μg을간역묘조여10μg을간역묘조간항-HBs양전솔차이유통계학의의（χ2＝0．001，P＜0．017）。결론：60μg 을간역묘구유여20μg을간역묘、10μg을간역묘동양적안전성，성인을간역감자접충60μg을간역묘일침면역효과우우20μg을간역묘、10μg을간역묘삼침적면역효과。
Objective :To evaluate the safety and the immunization effect of hepatitis B vaccine in adults by different dosages and schedules .Methods:According to the principle of voluntariness hepatitis B vaccination by dosage 60 ,20 or 10 micrograms at 0 month ,0 ,1 ,6 month or 0 ,1 ,6 month was conducted among the adults who were susceptible to hepatitis B virus .Comparisons on adverse reaction rates or anti-HBs positive rates between three groups were done by using chi-square test .Results :There were no significant differences in adverse reaction rate between three groups (χ2 =5 .09 ,P>0 .05) .Anti-HBs positive rates of 60 ,20 or 10 micrograms dose groups were 96 .7% ,90 .5% 和88 .1% ,re-spectively .There were significant differences in anti-HBs positive rates between 60 and 20 micrograms dose groups(χ2=0 .010 ,P<0 .017) ,60 and 10 micrograms dose groups(χ2 =0 .001 ,P<0 .017) .Conclusion :60 micrograms dose of hepatitis B vaccine has the same safety to 20 or 10 micrograms dose of vaccine .Immune response of 60 micrograms dose of hepatitis B vaccine at 0 month is better than 20 or 10 micrograms dose of vaccine at 0 ,1 ,6 month .