CAJ | 학술논문

目的：探讨急性心肌梗死患者的血脂水平与冠状动脉狭窄血管数之间、超敏C-反应蛋白（hs-CRP）与患者住院时间之间的关系。方法回顾性分析2012年6月至2013年10月住院治疗的121例急性心肌梗死患者的临床资料，包括ST段抬高型心肌梗死（STEMI）和非ST段抬高型心肌梗死（NSTEMI）患者的三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、脂蛋白（a）[LP（a）]、载脂蛋白B（apoB）、载脂蛋白A-1（apoA-1）、hs-CRP、冠状动脉造影提示的狭窄血管数和患者住院时间。结果 STEMI组与NSTEMI组血脂水平比较，差异无统计学意义（P>0.05）。LP（a）水平与冠状动脉狭窄血管数呈直线正相关，且NSTEMI组（r=0.544，P＜0.05）的密切程度高于STEMI组（r=0.436，P＜0.05）。而LDL-C、HDL-C、apoB、apoA-1、apoB/apoA-1与冠状动脉狭窄血管数之间没有直线相关性。患者此次住院时间与hs-CRP呈直线正相关（r=0.347，P=0.027）。结论 LP（a）在一定程度上能估计冠状动脉病变范围，hs-CRP与患者住院时间有一定相关性，能在一定程度上推测患者的病情及预后。
목적：탐토급성심기경사환자적혈지수평여관상동맥협착혈관수지간、초민C-반응단백（hs-CRP）여환자주원시간지간적관계。방법회고성분석2012년6월지2013년10월주원치료적121례급성심기경사환자적림상자료，포괄ST단태고형심기경사（STEMI）화비ST단태고형심기경사（NSTEMI）환자적삼선감유（TG）、총담고순（TC）、저밀도지단백담고순（LDL-C）、고밀도지단백담고순（HDL-C）、지단백（a）[LP（a）]、재지단백B（apoB）、재지단백A-1（apoA-1）、hs-CRP、관상동맥조영제시적협착혈관수화환자주원시간。결과 STEMI조여NSTEMI조혈지수평비교，차이무통계학의의（P>0.05）。LP（a）수평여관상동맥협착혈관수정직선정상관，차NSTEMI조（r=0.544，P＜0.05）적밀절정도고우STEMI조（r=0.436，P＜0.05）。이LDL-C、HDL-C、apoB、apoA-1、apoB/apoA-1여관상동맥협착혈관수지간몰유직선상관성。환자차차주원시간여hs-CRP정직선정상관（r=0.347，P=0.027）。결론 LP（a）재일정정도상능고계관상동맥병변범위，hs-CRP여환자주원시간유일정상관성，능재일정정도상추측환자적병정급예후。
Objective To explore the correlation of blood lipid level of patients with acute myocardial infarction (AMI) with the number of coronary artery narrow vessels and the length of stay (LOS) of patients with high-sensitive C-reactive protein (hs-CRP). Methods Retrospective analysis was conducted on the clinical data of 121 AMI patients ,who were hospitalized from June 2012 to October 2013,to collect the triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterin(LDL-C), high-density lipoprotein cholesterin (HDL-C),lipoprotein a [LP (a)],apolipoprotein B (apoB),apolipoprotein A-1 (apoA-1),hs-CRP,number of coronary artery narrow vessels and LOS of the patients with ST-segment elevation myocardial infarction (STEMI) (STEMI group) and non-ST-segment elevation myocardial infarction(NSTEMI)(NSTEMI group). Results There was no statisti-cally significant difference on blood lipid level between the STEMI group and NSTEMI group (P>0.05). LP(a) level had an positive linear relationship with number of coronary artery narrow vessels, moreover, the correlation coefficient of the NSTEMI group(R=0.544,P<0.05) was higher than that of the STEMI(R=0.436,P<0.05). However,the number of coronary artery narrow vessels had no linear relationship with LDL-C,HDL-C,apoB,apoA-1 and apoB/apoA-1. The LOS of the patients was positively correlated with hs-CRP(R=0.347,P=0.027). Conclusion LP(a) level can estimate the scope of coronary artery lesion to some extent,hs-CRP has certain correlation with the LOS,and it can diagnose the condition and prognosis of the patients to some extent.