CAJ | 학술논문

目的探讨精神分裂症患者血清蛋白和相关酶改变及其与代谢综合征的关系.方法 503名住院精神分裂症患者和60名健康自愿者接受调查,收集人口学资料和病史资料,检测血清蛋白质和酶水平,按国际糖尿病联盟标准诊断代谢综合征.结果精神分裂症患者血清蛋白水平[总蛋白(71.14±6.13) g/L、白蛋白(44.56±4.24) g/L、球蛋白(26.35±5.04)g/L、载脂蛋白A(10.97 ±0.27) g/L和载脂蛋白B(0.69 ±0.25) g/L低于对照组(79.96±6.10)g/L、(49.44±5.63)g/L、(30.52±4.00) g/L、(10.97±0.27)g/L和(0.69±0.25) g/L],尿素氮(4.36±1.36) mmol/L低于对照组(5.22±1.31) mmol/L,C-反应蛋白(3.17±6.58) mg/L高于对照组(1.35±1.83) mg/L,差异均具有统计学意义(P＜0.01)；丙氨酸氨基转移酶(24.28±32.76) IU/L、a-L岩藻糖苷酶(17.49±4.83) U/L、腺苷脱氢酶(17.81±5.67) U/L和肌酸激酶同工酶(10.50±4.92) IU/L高于对照组(18.12±9.77)IU/L、(15.98±3.58)IU/L、(11.75±5.48) IU/L、和(9.12±3.62) IU/L,AST同工酶(5.97±4.97) U/L低于对照组(7.05±6.72) U/L,差异均具有统计学意义(P＜0.01)；精神分裂症伴代谢综合征患者丙氨酸氨基转移酶、碱性磷酸酶、γ-谷氨酰转移酶、a-L岩藻糖苷酶、AST同工酶和胱抑素C高于非代谢综合征患者,差异具有统计学意义(P＜0.05).结论精神分裂症患者存在显著的蛋白质和酶代谢异常,许多酶代谢异常与代谢综合征显著关联.
목적 탐토정신분렬증환자혈청단백화상관매개변급기여대사종합정적관계.방법 503명주원정신분렬증환자화60명건강자원자접수조사,수집인구학자료화병사자료,검측혈청단백질화매수평,안국제당뇨병련맹표준진단대사종합정.결과 정신분렬증환자혈청단백수평[총단백(71.14±6.13) g/L、백단백(44.56±4.24) g/L、구단백(26.35±5.04)g/L、재지단백A(10.97 ±0.27) g/L화재지단백B(0.69 ±0.25) g/L저우대조조(79.96±6.10)g/L、(49.44±5.63)g/L、(30.52±4.00) g/L、(10.97±0.27)g/L화(0.69±0.25) g/L],뇨소담(4.36±1.36) mmol/L저우대조조(5.22±1.31) mmol/L,C-반응단백(3.17±6.58) mg/L고우대조조(1.35±1.83) mg/L,차이균구유통계학의의(P＜0.01)；병안산안기전이매(24.28±32.76) IU/L、a-L암조당감매(17.49±4.83) U/L、선감탈경매(17.81±5.67) U/L화기산격매동공매(10.50±4.92) IU/L고우대조조(18.12±9.77)IU/L、(15.98±3.58)IU/L、(11.75±5.48) IU/L、화(9.12±3.62) IU/L,AST동공매(5.97±4.97) U/L저우대조조(7.05±6.72) U/L,차이균구유통계학의의(P＜0.01)；정신분렬증반대사종합정환자병안산안기전이매、감성린산매、γ-곡안선전이매、a-L암조당감매、AST동공매화광억소C고우비대사종합정환자,차이구유통계학의의(P＜0.05).결론 정신분렬증환자존재현저적단백질화매대사이상,허다매대사이상여대사종합정현저관련.
Objective To investigate changes of serum proteins and related enzymes in patients with schizophrenia and its relationship to metabolic syndrome.Methods Five hundred and three inpatients with schizophrenia and 60 healthy volunteer were selected in this study.The demographic information and medical history data of them were recorded and levels of serum proteins and enzymes were measured,and the metabolic syndrome (MS) was diagnosed according to IDF criteria.Results Serum protein contents of schizophrenic patients (total protein (71.14 ±6.13) g/L,albumin (44.56 ±4.24)g/L,globulin(26.35 ±5.04) g/L,apoprotein A(10.97 ± 0.27) g/L,and apoprotein B (0.69 ± 0.25) g/L) were significantly lower than control group (79.96 ± 6.10) g/L,(49.44 ±5.63) g/L,(30.52 ±4.00) g/L,(10.97 ±0.27) g/L,and(0.69 ±0.25)g/L (P＜0.01).Urea nitrogen ((4.36± 1.36) mmol/L) was lower than control group ((5.22 ± 1.31) mmol/L) and C-reaction protein ((3.17 ± 6.58) mg/L) was higher than control group (1.35 ± 1.83) (P ＜ 0.01).Alanine aminotransferase ((24.28 ± 32.76) IU/L),a-L Fucosidase((17.49 ± 4.83) U/L),adenosine dehydrogenase((17.81 ± 5.67) U/L),and creatine kinase isoenzyme((10.50 ±4.92)IU/L) were higher than control group (18.12 ±9.77)IU/L,(15.98 ± 3.58)U/L,(11.75 ±5.48) U/L,and (9.12 ±3.62)IU/L,P＜0.01),but AST isoenzyme ((5.97 ±4.97) U/L)was lower than control group ((7.05 ± 6.72) U/L).Alanine Aminotransferase,alkaline phosphatase,γ-glutamyl transpeptidase,and a-L Fucosidase,AST isoenzyme and cystatin-c of schizophrenic patients with MS were significantly higher than non-MS patients(P ＜ 0.05).Conclusion There are significant metabolic disorders of proteins and enzymes in patients with schizophrenia,and abnormal changes of many enzymes are significantly associated with metabolic syndrome.