CAJ | 학술논문

目的研究清醒睡眠节律对局灶性癫痫患者发作间期癫痫样放电(ⅡD)的影响.方法收集2011年1月至2012年1月,在北京三博脑科医院癫痫内科经过住院期间癫痫手术前综合评估的癫痫患者,共44例,采用电势定位的方法定位棘波最大电势点,作为棘波的位置,计数清醒期、快速眼动睡眠期(REM),非快速眼动睡眠Ⅰ-Ⅱ期(NREMⅠ-Ⅱ),和非快速眼动睡眠Ⅲ-Ⅳ期(NREMⅢ-Ⅳ)ⅡD的次数和ⅡD范围,用方差分析比较了各期的ⅡD的次数和范围.结果 ⅡD的次数在NREM Ⅰ-Ⅱ期(中位数:29次)和NREMⅢ-Ⅳ(中位数:56次),比REM期(中位数:1次)和清醒期(中位数:5次)明显增多(P＜0.05).ⅡD的分布范围用所涉及的电极个数计算,在NREM Ⅰ-Ⅱ期[(1.06±0.85)个]和NREMⅢ-Ⅳ[(2.04±1.10)个]比REM期[(1.94±1.18)个]和清醒期[(0.86±0.66)个]明显增大(P＜0.05).结论 ⅡD在NREMⅠ-Ⅱ、NREMⅢ-Ⅳ期,出现频率最高,分布范围最广,在清醒期和REM期,ⅡD出现频率明显降低,分布明显局限.
목적 연구청성수면절률대국조성전간환자발작간기전간양방전(ⅡD)적영향.방법 수집2011년1월지2012년1월,재북경삼박뇌과의원전간내과경과주원기간전간수술전종합평고적전간환자,공44례,채용전세정위적방법정위극파최대전세점,작위극파적위치,계수청성기、쾌속안동수면기(REM),비쾌속안동수면Ⅰ-Ⅱ기(NREMⅠ-Ⅱ),화비쾌속안동수면Ⅲ-Ⅳ기(NREMⅢ-Ⅳ)ⅡD적차수화ⅡD범위,용방차분석비교료각기적ⅡD적차수화범위.결과 ⅡD적차수재NREM Ⅰ-Ⅱ기(중위수:29차)화NREMⅢ-Ⅳ(중위수:56차),비REM기(중위수:1차)화청성기(중위수:5차)명현증다(P＜0.05).ⅡD적분포범위용소섭급적전겁개수계산,재NREM Ⅰ-Ⅱ기[(1.06±0.85)개]화NREMⅢ-Ⅳ[(2.04±1.10)개]비REM기[(1.94±1.18)개]화청성기[(0.86±0.66)개]명현증대(P＜0.05).결론 ⅡD재NREMⅠ-Ⅱ、NREMⅢ-Ⅳ기,출현빈솔최고,분포범위최엄,재청성기화REM기,ⅡD출현빈솔명현강저,분포명현국한.
Objective To investigate the effects of circadian rhythm on interictal epileptiform discharges in patients with localization-related epilepsy.Methods Patients diagnosed with epilepsy in Sanbo Brain Hospital from January 2011 to January 2012 participated in this study.All patients were subjected to comprehensive evaluation,which included prolonged video-electroencephalogram (EEG),magnetic resonance imaging.Intracranial electrodes,PET,SPECT were also adopted if necessary.Circadian rhythm was divided into four stages:REM,NREM Ⅰ-Ⅱ,NREM Ⅲ-Ⅳ,and waking.The amount and distribution of ⅡD were compared by ANOVA.Results Significant differences in the amount and distribution of ⅡD were found among NREM Ⅰ-Ⅱ,NREM Ⅲ-Ⅳ,REM,and waking.However,no differences in the amount and distribution of ⅡD were noted between NREM Ⅰ-Ⅱ and NREM Ⅲ-Ⅳ as well as between REM and waking.Conclusion The amount of ⅡD is higher in NREM than in REM and waking;thus,NREM is more sensitive to diagnose epilepsy.The distribution of ⅡD in REM and waking is more restricted than that in NREM.