CAJ | 학술논문

目的探讨无神经症状梅毒患者和健康对照被试(health controls,HC)之间工作记忆的差异.方法对30例无神经症状梅毒患者及与其人口学资料相匹配的35名HC被试采用字母版2-back工作记忆任务,比较两组正确率及反应时间的差异.结果所有被试在排除焦虑和抑郁情绪情况下,梅毒患者组不仅存在词汇流畅性以及数字广度障碍,而且存在工作记忆的损伤.梅毒患者组在工作记忆的正确率与反应时均差于HC组[分别为:(65.31±8.78)％,(71.00±9.64)％；(1521.14±290.57) ms,(1296.08±253.20)ms],差异有统计学意义(分别为:t=-2.472,P=0.016;t=3.337,P=0.001).梅毒患者的实验反应时与患者的确诊时间呈负相关(r=-0.362,P=0.049).结论无神经症状梅毒患者患者存在工作记忆的损伤,可能与梅毒螺旋体对梅毒患者患者中枢神经系统的损伤有关.
목적 탐토무신경증상매독환자화건강대조피시(health controls,HC)지간공작기억적차이.방법 대30례무신경증상매독환자급여기인구학자료상필배적35명HC피시채용자모판2-back공작기억임무,비교량조정학솔급반응시간적차이.결과 소유피시재배제초필화억욱정서정황하,매독환자조불부존재사회류창성이급수자엄도장애,이차존재공작기억적손상.매독환자조재공작기억적정학솔여반응시균차우HC조[분별위:(65.31±8.78)％,(71.00±9.64)％；(1521.14±290.57) ms,(1296.08±253.20)ms],차이유통계학의의(분별위:t=-2.472,P=0.016;t=3.337,P=0.001).매독환자적실험반응시여환자적학진시간정부상관(r=-0.362,P=0.049).결론 무신경증상매독환자환자존재공작기억적손상,가능여매독라선체대매독환자환자중추신경계통적손상유관.
Objective To investigate the differences of the working memory tasks' performance between the patients with no neurological syphilis disease and the health controls (HC).Methods 2-back test of N-back task paradigm were applied to measure the performances of working memory.A total of 30 patients with syphilis disease were compared with 35 gender-,age-,years of education-matched healthy persons,then compared the accurate rate and reaction time on the tasks between the two groups.Results Participants with anxiety or depression had to be excluded.The results showed that patients impaired on working memory task.The accurate rate and reaction time of the working memory of the patients was worse than that of the healthy persons ((65.31 ± 8.78) ％ vs (71.00 ±9.64)％ ;(1521.14 ±290.57)ms vs (1296.08 ±253.20)ms respectively) (t=-2.472,P=0.016;t=3.337,P =0.001 respectively).The study indicated the reaction time of the working memory for the patients was negative correlation to the age of final diagnosis (r =-0.362,P =0.049).Conclusion The patients with no neurological syphilis disease show impairment on working memory.This probably because treponema pallidum injures the central nervous system.