CAJ | 학술논문

目的：探讨胎儿早孕期三尖瓣反流在染色体异常筛查中的临床意义。方法：对1262例孕11～14周胎儿进行染色体异常筛查，所有胎儿行超声检查，观察胎儿生长发育除外严重胎儿畸形，测量头臀长、颈项透明层、三尖瓣频谱等，可疑者进一步行染色体检查，所有胎儿进行随访。结果：接受筛查的1262例孕妇中，共发现三尖瓣反流68例，1239例染色体正常胎儿中，发现三尖瓣反流54例（4．4％），23例染色体异常胎儿中，发现三尖瓣反流14例（61％）。这一超声特征诊断染色体异常敏感性和特异性分别为61％、95％。无论染色体正常与否，共发现先天性心脏畸形胎儿28例。先天性心脏畸形胎儿中三尖瓣反流发生率64％，未合并心脏畸形胎儿者三尖瓣反流发生率为1．5％。结论：三尖瓣反流是孕早期胎儿染色体异常的有效预测指标。
목적：탐토태인조잉기삼첨판반류재염색체이상사사중적림상의의。방법：대1262례잉11～14주태인진행염색체이상사사，소유태인행초성검사，관찰태인생장발육제외엄중태인기형，측량두둔장、경항투명층、삼첨판빈보등，가의자진일보행염색체검사，소유태인진행수방。결과：접수사사적1262례잉부중，공발현삼첨판반류68례，1239례염색체정상태인중，발현삼첨판반류54례（4．4％），23례염색체이상태인중，발현삼첨판반류14례（61％）。저일초성특정진단염색체이상민감성화특이성분별위61％、95％。무론염색체정상여부，공발현선천성심장기형태인28례。선천성심장기형태인중삼첨판반류발생솔64％，미합병심장기형태인자삼첨판반류발생솔위1．5％。결론：삼첨판반류시잉조기태인염색체이상적유효예측지표。
Objective To investigate the clinical significance of fetal tricuspid regurgitation (TR) in the screening of chromosomal abnormalities at the first-trimester. Methods Screening for chromosomal abnormalities was carried out in 1 262 fetuses at 11+0 to 13+6 weeks. Ultrosound was performed to measure crown rump length and nuchal translucency (NT) thickness, and to acquire tricuspid waveform. All the neonates were followed up for 6 months after birth. Results Among the 1 262 fetuses, 68 were found to have TR. TR was present in 54 (4.4%) of the 1 239 chromosomally normal fetuses, and in 14 (61%) of the 23 with chromosomal abnormalities. Cardiac malformations were detectable in 28 fetuses. The prevalence of TR was 64%in those with cardiac malformations and 1.5%in those without cardiac malformations. Conclusions Tricuspid regurgitation is an effective predictor for the detection of fetal chromosomal abnormalities at the first trimester.