CAJ | 학술논문

目的：考察紫杉醇长循环热敏脂质体（PLTL）对Lewis肺癌荷瘤小鼠的药效学。方法：建立Lewis肺癌肿瘤模型，随机分为5组，对照组、加热组、紫杉醇注射液（PTX）组、紫杉醇热敏脂质体（PTL）组和PLTL组，局部联合热疗，观察小鼠生活状态，监测肿瘤的体积及瘤重，对肿瘤组织切片进行HE染色，观察肿瘤细胞的形态学变化，采用流式细胞术检测肿瘤细胞的凋亡率。结果：PTX、PTL组和PLTL组的抑廇率分别为48．87％、57．22％和78．87％，肿瘤细胞凋亡率分别为（42．7±3．8）％，（54．6±2．9）％和（69．7±5．0）％。结论：PLTL与PTX和PTL相比，PLTL具有明显的热敏靶向性，与局部热疗相结合显著提高了紫杉醇的治疗效果。
목적：고찰자삼순장순배열민지질체（PLTL）대Lewis폐암하류소서적약효학。방법：건립Lewis폐암종류모형，수궤분위5조，대조조、가열조、자삼순주사액（PTX）조、자삼순열민지질체（PTL）조화PLTL조，국부연합열료，관찰소서생활상태，감측종류적체적급류중，대종류조직절편진행HE염색，관찰종류세포적형태학변화，채용류식세포술검측종류세포적조망솔。결과：PTX、PTL조화PLTL조적억류솔분별위48．87％、57．22％화78．87％，종류세포조망솔분별위（42．7±3．8）％，（54．6±2．9）％화（69．7±5．0）％。결론：PLTL여PTX화PTL상비，PLTL구유명현적열민파향성，여국부열료상결합현저제고료자삼순적치료효과。
Objective To investigate the tumor inhibition effect of paclitaxel long-circulating thermo sensitive liposomes (PLTL) in mice bearing Lewis lung carcinoma cells. Methods A tumor-bearing mouse model was established, and the mice were randomly divided into five groups: control, heating, paclitaxel (PTX), paclitaxel thermo sensitive liposomes (PTL), and PLTL groups. The living status was observed in the mice. The volume and weight of the tumor were measured. The morphological changes in the tumor cells were observed f by HE staining and apoptosis of the tumor cells was determined by flow cytometry. Results The inhibition rate of tumor in PTX, PTL and PLTL groups was 48.87%, 57.22%and 78.87%, respectively. The apoptotic rate of tumor cell in PTX, PTL and PLTL groups was (42.7 ± 3 .8)%, (54.6 ± 2.9)%and (69.7 ± 5.0)%, respectively. Conclusions PLTL, as compared with PTX and PTL, has an evident thermo sensitive feature and increases the anticancer effect of paclitaxel remarkably in combination with local hyperthermia.