CAJ | 학술논문

以羟基磷灰石(H AP )表面羟基为引发基团,通过开环聚合法将丙交酯以共价化学键的方式接枝到 HAP 表面,得到 PLA-g-HAP；再引入具有良好细胞相容性的马来酸酐和具有良好骨诱导性的力生长因子(MGF-Ct24E ),得到 MGF-Ct24E-MPLA-g-H AP。借助红外光谱分析、氨基酸分析、热性能分析、力学性能分析和电镜分析,对上述材料的结构及性能进行了表征。结果表明,最终产物中 MGF-Ct24E 的接枝率为22.63%,玻璃化转变温度为58.62℃,力学性能有明显增强,并具备了三维互通孔状结构和骨诱导生物活性。该材料有望作为新型仿生骨基质材料得到应用。
이간기린회석(H AP )표면간기위인발기단,통과개배취합법장병교지이공개화학건적방식접지도 HAP 표면,득도 PLA-g-HAP；재인입구유량호세포상용성적마래산항화구유량호골유도성적력생장인자(MGF-Ct24E ),득도 MGF-Ct24E-MPLA-g-H AP。차조홍외광보분석、안기산분석、열성능분석、역학성능분석화전경분석,대상술재료적결구급성능진행료표정。결과표명,최종산물중 MGF-Ct24E 적접지솔위22.63%,파리화전변온도위58.62℃,역학성능유명현증강,병구비료삼유호통공상결구화골유도생물활성。해재료유망작위신형방생골기질재료득도응용。
Biomimetic bone matrix materials was a kind of scaffold material which could be induction of bone seed cells transplantation and promotion of the growth of new bone,should have good properties of biodegrad-ability,biocompatibility,mechanical strength and osteoinduction.Based on the preliminary research of the bio-mimetic bone matrix materials of polylactic acid (PLA),prepared covalent chemical bonds grafted PLA-g-HAP with initiation of surface hydroxyl groups of hydroxyapatite (HAP)and ring-opening polymerization of lactide, and prepared MGF-Ct24E-MPLA-g-HAP with introduction of maleic anhydride with good cell compatibility and growth factor (MGF-Ct24E)with good osteoinduction.The structure and properties of materials had been characterized by infrared spectrum analysis,amino acid analysis,thermal performance analysis,mechanical per-formance analysis and electron microscopy (SEM)analysis.Results show that the final product with the 3D pore structure and biological activity of osteoinduction,which MGF-Ct24E grafting was 22.63%,glass transi-tion temperature was 58.62 ℃,mechanical properties have obvious enhancement.Therefore,the material was expected to be applied as a new type of bionic bone matrix materials.