CAJ | 학술논문

用高碘酸钠将再生纤维素膜(RC)部分氧化,得到具有醛基的2,3-二醛纤维素膜(DARC,醛基含量为6.11%),再通过席夫碱反应将胶原蛋白固定到DARC膜上,制备得到DARC-Col复合敷料。SEM结果显示DARC-Col复合敷料具有多孔网络结构。该材料具有良好的机械性能(拉伸强度78.09 MPa,断裂伸长率9.59%),溶胀性能(182%),透湿性(703.72 g/m2·d)和保水性(20%)。NIH-3T3小鼠成纤维细胞实验结果表明,该材料能有效促进细胞的生长和增殖,具有作为理想的伤口敷料应用于伤口修复治疗的巨大潜能。
용고전산납장재생섬유소막(RC)부분양화,득도구유철기적2,3-이철섬유소막(DARC,철기함량위6.11%),재통과석부감반응장효원단백고정도DARC막상,제비득도DARC-Col복합부료。SEM결과현시DARC-Col복합부료구유다공망락결구。해재료구유량호적궤계성능(랍신강도78.09 MPa,단렬신장솔9.59%),용창성능(182%),투습성(703.72 g/m2·d)화보수성(20%)。NIH-3T3소서성섬유세포실험결과표명,해재료능유효촉진세포적생장화증식,구유작위이상적상구부료응용우상구수복치료적거대잠능。
In this study,an approach to prepare regenerated cellulose/collagen composite dressing was pro-posed.Firstly,regenerated cellulose membrane was oxidized by periodate oxidation for the preparation of 2,3-dialdehyde cellulose (DARC,the dialdehyde content was 6 .1 1%),and then it was reacted with collagen to ob-tain the target DARC-Col composite dressing by Schiff base reaction.The scanning electron microscopy re-vealed that DARC-Col composite dressing exhibited the refined network structures.In addition,the composite dressing showed novel mechanical properties (the strain was 78.09 MPa,the stress was 9.59%),good equilib-rium-swelling ratio (182%),good air permeability (703.72 g/m2 ·d)and excellent water retaining property (20%).Furthermore,the test of NIH3T3 mice fibroblast cells indicated that DARC-Col could promote cell growth and proliferation.The DARC-Col composite dressing showed great potential as ideal wound dressing for the wound repair application.