CAJ | 학술논문

理想的根管充填材料应具有良好根管封闭性能与抗菌作用。通过在具有良好可调控性自固化聚氨酯中添加无机抗菌剂磷酸银,经先制备预聚体,再进一步聚合的方法制备新型载磷酸银聚氨酯基根管充填材料(Ag3 PO4/PU)。红外光谱分析表明,制得的聚氨酯预聚物由异氰酸根(-NCO)封端,-NCO 的转换率为75.2%,经进一步反应制得的聚氨酯高聚物中-NCO 转换率为96.8%。依照根管充填材料的 ISO标准评价了材料理化性能,结果显示其理化性能符合ISO 标准的要求；抑菌环、抗细菌粘附和抑菌率实验结果表明,Ag3 PO4/PU能有效抑制细菌粘附和增殖,与细菌接触培养7 h 后抑菌率>90%,是一种有应用潜力的新型抗菌根管充填材料。
이상적근관충전재료응구유량호근관봉폐성능여항균작용。통과재구유량호가조공성자고화취안지중첨가무궤항균제린산은,경선제비예취체,재진일보취합적방법제비신형재린산은취안지기근관충전재료(Ag3 PO4/PU)。홍외광보분석표명,제득적취안지예취물유이청산근(-NCO)봉단,-NCO 적전환솔위75.2%,경진일보반응제득적취안지고취물중-NCO 전환솔위96.8%。의조근관충전재료적 ISO표준평개료재료이화성능,결과현시기이화성능부합ISO 표준적요구；억균배、항세균점부화억균솔실험결과표명,Ag3 PO4/PU능유효억제세균점부화증식,여세균접촉배양7 h 후억균솔>90%,시일충유응용잠력적신형항균근관충전재료。
An ideal root canal sealer should possess capacity to seal the cavity completely and has good antibacte-rial ability.In this paper,a novel injectable self-setting silver phosphate loaded polyurethane (Ag3PO4/PU)an-tibacterial root canal sealer was developed via incorporation Ag3 PO4 into PU matrix by two step.The fourier transform infrared spectroscopy (FT-IR)analysis indicated that pre-polymer of polyurethane (PU)with isocya-nate (-NCO)sealing side was prepared in first step and the percent conversion of the -NCO was 75.2%.The final Ag3 PO4/PU root canal sealer was formed through further polymerization of the pre-polymer with other re-agents and the percent conversion of the -NCO could reach 96.8%.The physicochemical properties were eval-uated according to the ISO standards for root canal sealer and the results indicated that the physicochemical per-formance could meet requirements of the ISO standards.The antibacterial abilities of the fabricated Ag3 PO4/PU root canal sealer to S.aureus were studied through inhibition zone test,anti-adhension test and bacteriostat-ic rate test,the results suggested that the PU/Ag3PO4 had good antibacterial properties.This novel injectable self-setting antibacterial root canal sealer has a great potential to be used in clinic.