CAJ | 학술논문

目的：探讨脑胶质瘤术后放疗联合替莫唑胺化疗同步与序贯疗法治疗的临床效果。方法将我院收治的46例脑胶质瘤术后患者，随机分为对照组和观察组。对照组采用放疗联合替莫唑胺序贯疗法治疗，观察组采用放疗联合替莫唑胺同步疗法治疗。比较2组无病生存期、治疗过程中不良反应发生情况。结果观察组无病生存期显著长于对照组，差异有统计学意义（P＜0.05）。2组不良反应发生率经统计学分析，差异无统计学意义（P＞0.05）。结论同步放化疗可显著延长患者的无病生存期，不增加不良反应，为脑胶质瘤术后较好的治疗方案。
목적：탐토뇌효질류술후방료연합체막서알화료동보여서관요법치료적림상효과。방법장아원수치적46례뇌효질류술후환자，수궤분위대조조화관찰조。대조조채용방료연합체막서알서관요법치료，관찰조채용방료연합체막서알동보요법치료。비교2조무병생존기、치료과정중불량반응발생정황。결과관찰조무병생존기현저장우대조조，차이유통계학의의（P＜0.05）。2조불량반응발생솔경통계학분석，차이무통계학의의（P＞0.05）。결론동보방화료가현저연장환자적무병생존기，불증가불량반응，위뇌효질류술후교호적치료방안。
Objective To study the clinical effect of the radiotherapy combined with synchronizing chemotherapy or se-quential chemotherapy of temozolomide after glioma surgery.Methods 46 patients after glioma surgery were randomly divided into control group and observation group. Control group adopted radiotherapy combined with temozolomide sequential therapy , observation group adopted radiotherapy combined with temozolomide synchronizing therapy. disease free survival time ,adverse reactions of two groups were compared in the process of treatment.Results free survival time of observation group were signif-icantly longer than that of control group ,the difference was statistically significant (P<0.05). There was no significant differ-ence in incidence of adverse reactions of two groups ,(P>0.05).Conclusion concurrent chemoradiotherapy can significantly prolong the disease free survival time of patients with cerebral gliomas after surgery ,without increasing side effects ,it’s a bet-ter treatment for glioma surgery.