中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2014年
14期
4-6
,共3页
穹窿下器%高血压%透射电镜%水肿%大鼠
穹窿下器%高血壓%透射電鏡%水腫%大鼠
궁륭하기%고혈압%투사전경%수종%대서
Subfornical organ%Hypertension%Transmission electron microscopy%Edema%Rats
目的：观察高血压大鼠不同时期穹窿下器的水肿变化。方法雌性Wistar大鼠予以左旋硝基精氨酸（L-NNA）15 mg/（kg · d）腹腔注射，成功制备高血压动物模型。随机选择对照组、用药2周组、用药4周组、用药8周组，常规经心灌注固定取脑，取材后经处理用透射电镜观察高血压不同时期穹窿下器的水肿改变。结果随着血压的升高，穹窿下器的水肿逐渐加重，当血压稳定后，水肿减轻。结论穹窿下器在高血压不同时期的水肿改变与血压改变呈一致性。
目的：觀察高血壓大鼠不同時期穹窿下器的水腫變化。方法雌性Wistar大鼠予以左鏇硝基精氨痠（L-NNA）15 mg/（kg · d）腹腔註射，成功製備高血壓動物模型。隨機選擇對照組、用藥2週組、用藥4週組、用藥8週組，常規經心灌註固定取腦，取材後經處理用透射電鏡觀察高血壓不同時期穹窿下器的水腫改變。結果隨著血壓的升高，穹窿下器的水腫逐漸加重，噹血壓穩定後，水腫減輕。結論穹窿下器在高血壓不同時期的水腫改變與血壓改變呈一緻性。
목적：관찰고혈압대서불동시기궁륭하기적수종변화。방법자성Wistar대서여이좌선초기정안산（L-NNA）15 mg/（kg · d）복강주사，성공제비고혈압동물모형。수궤선택대조조、용약2주조、용약4주조、용약8주조，상규경심관주고정취뇌，취재후경처리용투사전경관찰고혈압불동시기궁륭하기적수종개변。결과수착혈압적승고，궁륭하기적수종축점가중，당혈압은정후，수종감경。결론궁륭하기재고혈압불동시기적수종개변여혈압개변정일치성。
Objective To investigate the change in edema of the subfornical organ of hypertensive rats at different times.Methods Female Wistar rats were treated with L-nitro-arginine (L-NNA) 15 mg/(kg · d) at 8 :00 am ,8 :00 pm intrap-eritoneal injection twice ,and so animal models of hypertension were made successfully.Control group ,Medication for weeks (10)group ,4 weeks (10)group ,8 weeks (10)group were randomly selected. Brains were removed after conventional fixation was made by cardiac perfusion ;The change in edema of the subfornical organ at different stages of hypertension was observed by transmission electron microscopy after tissue was treated.Results With the increase in blood pressure ,edema of the subfor-nical organ became gradually serious ;when the blood pressure was stable ,edema was relieved.Conclusion the change in ede-ma of the subfornical organ at different stages of hypertension is consistent with the change of hypertension.
