CAJ | 학술논문

目的：研究深圳市宝安区女性人乳头瘤病毒（HPV）感染情况，以及不同年龄段 HPV 阳性率和各亚型的分布情况。方法采用聚合酶链式反应-反向斑点杂交法（PCR-RDB）对2011年1月至2012年12月在深圳市宝安区妇幼保健院就诊的患者（2627例）进行23种 HPV 基因分型检测。结果2627例样本中 HPV 阳性率为23．94％（629例）。其中单一低危型感染占15．10％，以 HPV43型为主；单一高危型感染占55．17％，以 HPV52、HPV16、HPV58型为主；混合感染占29．73％。15～＜21岁、21～＜31岁、31～＜41岁、41～50岁与＞50岁年龄组 HPV 感染率分别为50．0％、24．7％、20．8％、25．8％、42．1％，差异有统计学意义（P ＜0．05）。结论深圳市宝安地区 HPV 感染率为23．94％，基因型分布以 HPV 52、16、58、43型为主，15～20岁年龄段感染率高于其他年龄段。
목적：연구심수시보안구녀성인유두류병독（HPV）감염정황，이급불동년령단 HPV 양성솔화각아형적분포정황。방법채용취합매련식반응-반향반점잡교법（PCR-RDB）대2011년1월지2012년12월재심수시보안구부유보건원취진적환자（2627례）진행23충 HPV 기인분형검측。결과2627례양본중 HPV 양성솔위23．94％（629례）。기중단일저위형감염점15．10％，이 HPV43형위주；단일고위형감염점55．17％，이 HPV52、HPV16、HPV58형위주；혼합감염점29．73％。15～＜21세、21～＜31세、31～＜41세、41～50세여＞50세년령조 HPV 감염솔분별위50．0％、24．7％、20．8％、25．8％、42．1％，차이유통계학의의（P ＜0．05）。결론심수시보안지구 HPV 감염솔위23．94％，기인형분포이 HPV 52、16、58、43형위주，15～20세년령단감염솔고우기타년령단。
Objective To investigate the female human papillomavirus(HPV)infection situation in Baoan district,the HPV pos-itive rates in different age groups and the subtypes distribution.Methods PCR followed with reverse dot blot was performed to ex-amine 23 kinds of HPV genotypes in 2 627 female patients in our hospital from the January 2011 to December 2012.Results In 2 627 samples,the positive rate of HPV was 23.94% (629 cases),in which the infection rate of single low-risk type was 15.1%(95 cases),the main HPV genotype was HPV43 (7.79%);the infection rate of high-risk type was 55.17% (347 cases),the 3 most prevalent HPV genotypes were HPV52 (12.56%),HPV16 (9.86%)and HPV58 (7.79%).The multiple HPV infection ac-counted for 29.73% (187 cases).The HPV infection rates in different age groups were 50.0% in age 15-20 years,24.7% in age 21-30 years,20.8% in age 31-40 years,25.8% in age 41 -50 years,42.1% in age >50 years respectively,the differences had statistical significance.Conclusion The HPV infection rate is 23.94% in Bao′an district.The most prevalent HPV genotypes are HPV 52,16,58,43.Women in age 15-20 years old have a higher infection rate.