CAJ | 학술논문

目的：探讨急性缺血性脑卒中患者血清超敏 C 反应蛋白（hs-CRP）的水平变化及其临床意义。方法采用高灵敏度的全自动散射比浊免疫分析仪---BNⅡ检测急性缺血性脑卒中患者64例及同期来医院体检的健康体检者32例的血清 hs-CRP的水平变化，回顾性分析急性缺血性脑卒中患者的病例资料。结果急性缺血性脑卒中组 hs-CRP 阳性率是53．3％，体检组的hs-CRP 的阳性率为9％，二者具有显著性差异（P ＜0．05）；急性缺血性脑卒中组 hs-CRP 的整体水平不符合正态分布，中位数是4．26 mg/L，体检组的 hs-CRP 的平均水平（0．99±0．72）mg/L，二者具有显著性差异（P ＜0．05）；急性缺血性脑卒中男性组 hs-CRP 平均水平是（5．03±1．51）mg/L，急性缺血性脑卒中女性组 hs-CRP 平均水平是（2．79±1．09）mg/L，二者具有显著性差异（P ＜0．05）。结论急性缺血性脑卒中患者血清中 hs-CRP 水平较健康人群高，二者差异具有统计学意义（P ＜0．05）；年龄和性别很可能是影响急性缺血性脑卒中患者血清 hs-CRP 的因素，急性缺血性脑卒中患者中 hs-CRP 阳性的平均年龄较 hs-CRP 阴性高，有高血压、糖尿病史的中老年人群发生急性缺血性脑卒中的危险性较健康人群高。
목적：탐토급성결혈성뇌졸중환자혈청초민 C 반응단백（hs-CRP）적수평변화급기림상의의。방법채용고령민도적전자동산사비탁면역분석의---BNⅡ검측급성결혈성뇌졸중환자64례급동기래의원체검적건강체검자32례적혈청 hs-CRP적수평변화，회고성분석급성결혈성뇌졸중환자적병례자료。결과급성결혈성뇌졸중조 hs-CRP 양성솔시53．3％，체검조적hs-CRP 적양성솔위9％，이자구유현저성차이（P ＜0．05）；급성결혈성뇌졸중조 hs-CRP 적정체수평불부합정태분포，중위수시4．26 mg/L，체검조적 hs-CRP 적평균수평（0．99±0．72）mg/L，이자구유현저성차이（P ＜0．05）；급성결혈성뇌졸중남성조 hs-CRP 평균수평시（5．03±1．51）mg/L，급성결혈성뇌졸중녀성조 hs-CRP 평균수평시（2．79±1．09）mg/L，이자구유현저성차이（P ＜0．05）。결론급성결혈성뇌졸중환자혈청중 hs-CRP 수평교건강인군고，이자차이구유통계학의의（P ＜0．05）；년령화성별흔가능시영향급성결혈성뇌졸중환자혈청 hs-CRP 적인소，급성결혈성뇌졸중환자중 hs-CRP 양성적평균년령교 hs-CRP 음성고，유고혈압、당뇨병사적중노년인군발생급성결혈성뇌졸중적위험성교건강인군고。
Objective To explore the level of hypersensitive C-reactive protein (hs-CRP)in the patients with acute ischemic stroke(AIS)and its clinical significance.Methods The BNⅡhighly sensitive automatical scattering turbidimetric immunity analy-zer was adopted to detect serum hs-CRP level in 64 cases of AIS and contemporaneous 32 individuals with healthy physical examina-tion as the control group.The data of AIS cases were retrospectively analyzed.Results The positive rate of hs-CRP was 53.3% in the AIS group and 9% in the control group with statistically significant difference between them(P <0.05);the overall levels of hs-CRP in the AIS group was in inconformity to the normal distribution,the median was 4.26mg/L,which in the control group was (0.99 ± 0.72 )mg/L,there was statistically significant difference between them (P < 0.05 );the average level of hs-CRP was (5.03±1.51)mg/L in the AIS male group and (2.79 ± 1.09)mg/L in the AIS female group,the difference between them had sta-tostical significance(P <0.05).Conclusion The serum hs-CRP level in the AIS patients is higher than that in the healthy crowd with statistical difference(P <0.05).The age and sex may be the causes influencing serum level of hs-CRP in the AIS patients.The average age in the AIS patients with positive hs-CRP is higher than that with negative hs-CRP.Middle-aged and elderly people with hypertension and diabetes are much more dangerous than healthy people in getting AIS.