CAJ | 학술논문

目的：探讨血清中缺血个儿蛋白（IMA）、超敏 C 反应蛋白（hs-CRP）、肌红蛋白（MYO）、肌酸激酶同工酶（CK-MB）、超敏肌钙蛋白（hs-cTnT）在急性冠状动脉综合征（ACS）患者早期诊断的价值。方法测定99例健康对照组和94例 ACS 患者（其中不稳定性心绞痛40例，非 ST 段抬高的心肌梗死即非 Q 波心肌梗死20例，ST 段抬高的心肌梗死即 Q 波心肌梗死34例）中IMA、hs-CRP、MYO、CK-MB、hs-TNT 的含量。通过 ROC 曲线比较5种标志物在 ACS 早期诊断中的诊断效率、灵敏度、特异性、阴阳性预测值。结果血清中 IAM、hs-CRP、MYO、CK-MB、hs-cTnT 检测结果在病例组 UAP，NSTEMI，STEMI 3组和正常对照组间比较，差异均有统计学意义（P ＜0．05）。其中 IMA、hs-CRP、MYO、CK-MB、hs-cTnT 在 UAP 与 NSTEMI 组，UAP 与NSTEMI 组间比较，差异均有统计学意义（P ＜0．05），NSTEMI 与 STEMI 组间比较，差异均无统计学意义（P ＞0．05）。结论在ACS 中，多个指标的联合检测能取得早期诊断的价值。
목적：탐토혈청중결혈개인단백（IMA）、초민 C 반응단백（hs-CRP）、기홍단백（MYO）、기산격매동공매（CK-MB）、초민기개단백（hs-cTnT）재급성관상동맥종합정（ACS）환자조기진단적개치。방법측정99례건강대조조화94례 ACS 환자（기중불은정성심교통40례，비 ST 단태고적심기경사즉비 Q 파심기경사20례，ST 단태고적심기경사즉 Q 파심기경사34례）중IMA、hs-CRP、MYO、CK-MB、hs-TNT 적함량。통과 ROC 곡선비교5충표지물재 ACS 조기진단중적진단효솔、령민도、특이성、음양성예측치。결과혈청중 IAM、hs-CRP、MYO、CK-MB、hs-cTnT 검측결과재병례조 UAP，NSTEMI，STEMI 3조화정상대조조간비교，차이균유통계학의의（P ＜0．05）。기중 IMA、hs-CRP、MYO、CK-MB、hs-cTnT 재 UAP 여 NSTEMI 조，UAP 여NSTEMI 조간비교，차이균유통계학의의（P ＜0．05），NSTEMI 여 STEMI 조간비교，차이균무통계학의의（P ＞0．05）。결론재ACS 중，다개지표적연합검측능취득조기진단적개치。
Objective To investigate the value of serum ischemia-modified protein (IMA),hypersensitivity C reaction protein (hs-CRP),myoglobin (MYO)creatine kinase MB (CK-MB)and ultra-sensitivity troponin T (hs-cTnT)in the early diagnosis of patients with acute coronary syndrome(ACS).Methods Serum levels of IMA,hs-CRP,MYO,CK-MB and hs-cTnT were meaused in 94 patients with ACS[including 40 cases of unstable angina pectoris(UAP),20 cases of non-ST segment elevation myocardial in-farction(NSTEMI),non-Q wave myocardial infarction and 34 cases of ST segment elevation myocardial infarction(STEMI),Q wave myocardial infarction]and 99 cases of controls.The efficiency,sensitivity,specificity,negative and positive predictive values in the early diagnosis of ACS were compared among 5 kinds markers by the ROC curve.Results The detection results of serum IMA,hs-CRP,MYO,CK-MB and hs-cTnT had statistically significant differences between the UAP,NSTEMI and STEMI groups with the normal control group (P <0.05),serum IMA,hs-CRP,MYO,CK-MB and hs-cTnT had statistically significant differences between the UAP group with the NSTEMI group and between the UAP group with STEMI group (P <0.05),but the difference between NSTEMI and STEMI group group was not statistically significant (P >0.05).Conclusion In the patients with ACS,the multiple indicators combined detection can achieve the early diagnostic value.