国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
14期
1846-1847,1850
,共3页
上皮性卵巢癌%CA125%肿瘤标志物%联合检测%诊断
上皮性卵巢癌%CA125%腫瘤標誌物%聯閤檢測%診斷
상피성란소암%CA125%종류표지물%연합검측%진단
epithelial ovarian cancer%CA125%tumor markers%combined detection%diagnosis
目的：探讨血清中 CA125、CA153、CA199和 CEA 四项肿瘤标志物的联合检测在上皮性卵巢癌诊断中的价值。方法采用化学发光免疫测定法检测54例卵巢癌患者和68例卵巢良性病变患者手术前，以及55例对照组（无妇科疾病及恶性疾病）妇女的血清样本中 CA125、CA153、CA199及 CEA 水平。应用统计软件 SPSS 13．0和 MedCalc 10．4．0．0回顾性分析检测结果。结果计算每种标志物单项及联合检测的敏感度、特异度及准确度。CA125三项指标分别为96．3％、64．7％和78．7％，高于其他单项指标。而联合检测中 CA125联合 CA153敏感度高达99．1％，准确度为79．5％，分别高于单项最佳的 CA125及其他联合检测方式（P ＜0．05）。结论使用 CA125与 CA153联合检测对上皮性卵巢癌的诊断价值优于 CA125单项检测及其他组合方式。
目的：探討血清中 CA125、CA153、CA199和 CEA 四項腫瘤標誌物的聯閤檢測在上皮性卵巢癌診斷中的價值。方法採用化學髮光免疫測定法檢測54例卵巢癌患者和68例卵巢良性病變患者手術前，以及55例對照組（無婦科疾病及噁性疾病）婦女的血清樣本中 CA125、CA153、CA199及 CEA 水平。應用統計軟件 SPSS 13．0和 MedCalc 10．4．0．0迴顧性分析檢測結果。結果計算每種標誌物單項及聯閤檢測的敏感度、特異度及準確度。CA125三項指標分彆為96．3％、64．7％和78．7％，高于其他單項指標。而聯閤檢測中 CA125聯閤 CA153敏感度高達99．1％，準確度為79．5％，分彆高于單項最佳的 CA125及其他聯閤檢測方式（P ＜0．05）。結論使用 CA125與 CA153聯閤檢測對上皮性卵巢癌的診斷價值優于 CA125單項檢測及其他組閤方式。
목적：탐토혈청중 CA125、CA153、CA199화 CEA 사항종류표지물적연합검측재상피성란소암진단중적개치。방법채용화학발광면역측정법검측54례란소암환자화68례란소량성병변환자수술전，이급55례대조조（무부과질병급악성질병）부녀적혈청양본중 CA125、CA153、CA199급 CEA 수평。응용통계연건 SPSS 13．0화 MedCalc 10．4．0．0회고성분석검측결과。결과계산매충표지물단항급연합검측적민감도、특이도급준학도。CA125삼항지표분별위96．3％、64．7％화78．7％，고우기타단항지표。이연합검측중 CA125연합 CA153민감도고체99．1％，준학도위79．5％，분별고우단항최가적 CA125급기타연합검측방식（P ＜0．05）。결론사용 CA125여 CA153연합검측대상피성란소암적진단개치우우 CA125단항검측급기타조합방식。
Objective To explore the value of the combined detection of four tumor markers of serum CA125,CA153,CA199 and CEA in the diagnosis of epithelial ovarian carcinoma(EOC).Methods The serum levels of CA125,CA153,CA199 and CEA were detected before operation in 54 cases of ovarian cancer and 68 cases of ovarial benign lesion and 55 healthy women as the con-trol group,by using chemiluminescent immunoassay(CLIA).The statistical software SPSS 13.0 and MedCalc 10.4.0.0 were used to retrospectively analyze the results.Results The sensitivity,specificity and accuracy of the single index detection and the com-bined detection were calculated.The sensitivity,specificity and accuracy of CA125 were 96.3%,64.7% and 78.7% respectively, which were higher than other single index′s.In the combine detection,the sensitivity and accuracy of the combined detection of CA125 and CA153 were 99.1% and 79.5% respectively,which were higher than those in the optimal single index CA125 and the other combined detection(P <0.05).Conclusion The combined detection of CA125 and CA153 is superior to the CA125 single in-dex detection in the diagnostic value for EOC.
