CAJ | 학술논문

目的：探讨维持性血液透析患者体内微炎症指标的变化情况，为临床治疗提供新思路。方法检测80例血透患者血清超敏 C 反应蛋白（hs-CRP）、白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）、同型半胱氨酸（Hcy）、丙二醛（MDA）、清蛋白（ALB）、转铁蛋白（Tf）、血红蛋白、全段甲状旁腺素（iPTH）水平，并与健康体检人群进行比较。结果维持性血液透析患者体内hs-CRP、IL-6、TNF-α水平明显高于健康人群（P ＜0．05），hs-CRP 水平与 IL-6、TNF-α、Hcy、MDA、iPTH 水平呈正相关，而与ALB、Tf 水平呈现负相关。结论维持性血液透析患者体内微炎症指标高于健康人，急需进行相关治疗。
목적：탐토유지성혈액투석환자체내미염증지표적변화정황，위림상치료제공신사로。방법검측80례혈투환자혈청초민 C 반응단백（hs-CRP）、백세포개소6（IL-6）、종류배사인자α（TNF-α）、동형반광안산（Hcy）、병이철（MDA）、청단백（ALB）、전철단백（Tf）、혈홍단백、전단갑상방선소（iPTH）수평，병여건강체검인군진행비교。결과유지성혈액투석환자체내hs-CRP、IL-6、TNF-α수평명현고우건강인군（P ＜0．05），hs-CRP 수평여 IL-6、TNF-α、Hcy、MDA、iPTH 수평정정상관，이여ALB、Tf 수평정현부상관。결론유지성혈액투석환자체내미염증지표고우건강인，급수진행상관치료。
Objective To investigate the changes of microinflammatory indicators in the maintenance hemodialysis patients to provide the new idea for clinical treatment.Methods Serum super sensitive C reactive protein (hs-CRP),interleukin 6(IL-6),tumor necrosis factorα(TNF-α),homocysteine(Hcy),malondialdehyde(MDA),albumin(ALB),hemoglobin,transferrin(Tf)levels and in-tact parathyroid hormone(iPTH)levels in 80 patients with hemodialysis were detected and the results were compared with those in the normal healthy population.Results The hs-CRP,IL-6,TNF-αlevels in the maintenance hemodialysis patients were significantly higher than those in the normal healthy population (P <0.05 ),the CRP level was positively correlated with IL-6,TNF-α,Hcy, MDA and iPTH levels and negatively correlated with ALB and Tf levels.Conclusion The microinflammatory indicators in the ma-intenance hemodialysis patients are higher than those in the normal people,which urgently need to conduct the related treatment.