国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
14期
1839-1841
,共3页
肖伟利%哈斯%任志宏%燕成岭%丁海涛
肖偉利%哈斯%任誌宏%燕成嶺%丁海濤
초위리%합사%임지굉%연성령%정해도
肝细胞癌%高尔基体跨膜糖蛋白%甲胎蛋白异质体-L3%转化生长因子-β1
肝細胞癌%高爾基體跨膜糖蛋白%甲胎蛋白異質體-L3%轉化生長因子-β1
간세포암%고이기체과막당단백%갑태단백이질체-L3%전화생장인자-β1
hepatocellular carcinoma%Golgi membrane protein%alpha-fetoprotein variant-L3%transforming growth factor beta 1
目的：探讨高尔基体糖蛋白73（GP73）、甲胎蛋白异质体-L3（AFP-L3）和转化生长因子β1（TGFβ1）联合检测在肝细胞癌（HCC）早期诊断中的临床价值。方法选取健康对照组48例，乙型肝炎组42例，肝炎后肝硬化组50例，HCC 组58例。对四组测试对象分别进行 GP73、AFP-L3、TGFβ1水平检测，并对结果进行分析比较。结果（1）不同组别间 GP73、AFP-L3、TGFβ1平均水平差异具有统计学意义（P ＜0．05）；（2）三指标联合检测，阳性检出率达到96．55％，高于两两指标联合检测和各指标单独检测。结论（1）GP73、AFP-L3、TGFβ1均可作为肝癌早期诊断血清标志物；（2）与传统肝癌标志物 AFP 比较，AFP-L3具有较高的敏感度和特异性，且在良性、恶性肝脏疾病的鉴别诊断中具有重要作用，是一个较好的肝癌诊断血清标志物；（3）三指标联合检测后明显提高了对肝癌的检出率，有较好的应用价值。
目的：探討高爾基體糖蛋白73（GP73）、甲胎蛋白異質體-L3（AFP-L3）和轉化生長因子β1（TGFβ1）聯閤檢測在肝細胞癌（HCC）早期診斷中的臨床價值。方法選取健康對照組48例，乙型肝炎組42例，肝炎後肝硬化組50例，HCC 組58例。對四組測試對象分彆進行 GP73、AFP-L3、TGFβ1水平檢測，併對結果進行分析比較。結果（1）不同組彆間 GP73、AFP-L3、TGFβ1平均水平差異具有統計學意義（P ＜0．05）；（2）三指標聯閤檢測，暘性檢齣率達到96．55％，高于兩兩指標聯閤檢測和各指標單獨檢測。結論（1）GP73、AFP-L3、TGFβ1均可作為肝癌早期診斷血清標誌物；（2）與傳統肝癌標誌物 AFP 比較，AFP-L3具有較高的敏感度和特異性，且在良性、噁性肝髒疾病的鑒彆診斷中具有重要作用，是一箇較好的肝癌診斷血清標誌物；（3）三指標聯閤檢測後明顯提高瞭對肝癌的檢齣率，有較好的應用價值。
목적：탐토고이기체당단백73（GP73）、갑태단백이질체-L3（AFP-L3）화전화생장인자β1（TGFβ1）연합검측재간세포암（HCC）조기진단중적림상개치。방법선취건강대조조48례，을형간염조42례，간염후간경화조50례，HCC 조58례。대사조측시대상분별진행 GP73、AFP-L3、TGFβ1수평검측，병대결과진행분석비교。결과（1）불동조별간 GP73、AFP-L3、TGFβ1평균수평차이구유통계학의의（P ＜0．05）；（2）삼지표연합검측，양성검출솔체도96．55％，고우량량지표연합검측화각지표단독검측。결론（1）GP73、AFP-L3、TGFβ1균가작위간암조기진단혈청표지물；（2）여전통간암표지물 AFP 비교，AFP-L3구유교고적민감도화특이성，차재량성、악성간장질병적감별진단중구유중요작용，시일개교호적간암진단혈청표지물；（3）삼지표연합검측후명현제고료대간암적검출솔，유교호적응용개치。
Objective To investigate the clinical value of the combined detection of Golgi protein 73 (GP73),alpha-fetoprotein variant-L3 (AFP-L3)and transforming growth factorβ1(TGFβ1)in the early diagnosis of hepatocellular carcinoma (HCC).Meth-ods 48 cases of healthy control,42 cases of hepatitis B,50 cases of posthepatitic cirrhosis and 58 cases of HCC were selected and detected GP73,AFP-L3 and TGFβ1.The detection results were compared among 4 groups.Results (1)The levels of GP73,AFP-L3 and TGFβ1 had statistical differences among 4 groups(P <0.05 );(2 )The positive rate of the 3-marker combined detection reached 96.55%,which was higher than that of the 2-marker combined detection and the single marker detection.Conclusion (1) GP73,AFP-L3 and TGFβ1 may be used as the serum indicators for the early diagnosis of HCC;(2)Compared with the traditional HCC marker AFP,AFP-L3 has relatively high sensitivity and specificity and has the important role in the differential diagnosis of benign and malignant diseases of the liver,which is considered as a better serum marker in the HCC diagnosis;(3)The 3-indicator combined detection can significantly improve the positive detection rate of HCC and has better application value.
