CAJ | 학술논문

目的：探讨尼莫地平对老年慢性脑供血不足（CCCI）患者认知功能及脑血流的影响。方法60例老年CCCI患者随机分为2组，对照组予阿司匹林、他汀类药物等对症治疗，观察组在此基础上加用尼莫地平片，观察治疗前后患者认知功能及脑血流的变化。结果治疗后观察组患者MMSE及MoCA总分均较治疗前显著改善，且明显优于对照组，差异均有统计学意义（P＜0.05）；治疗后双侧大脑中动脉MCAVs、MCAVm均较治疗前明显升高（P＜0.05），双侧大脑中动脉PI较治疗前明显下降（P＜0.05）。结论尼莫地平治疗老年CCCI可扩张脑血管，改善脑血流量，改善认知功能，且用药安全性好。
목적：탐토니막지평대노년만성뇌공혈불족（CCCI）환자인지공능급뇌혈류적영향。방법60례노년CCCI환자수궤분위2조，대조조여아사필림、타정류약물등대증치료，관찰조재차기출상가용니막지평편，관찰치료전후환자인지공능급뇌혈류적변화。결과치료후관찰조환자MMSE급MoCA총분균교치료전현저개선，차명현우우대조조，차이균유통계학의의（P＜0.05）；치료후쌍측대뇌중동맥MCAVs、MCAVm균교치료전명현승고（P＜0.05），쌍측대뇌중동맥PI교치료전명현하강（P＜0.05）。결론니막지평치료노년CCCI가확장뇌혈관，개선뇌혈류량，개선인지공능，차용약안전성호。
Objective To investigate the effects of nimodipine on cognitive function and cerebral blood flow in elderly pa-tients with chronic cerebral circulation insufficiency (CCCI) .Methods Sixty elderly patients with CCCI were randomly divided into two groups ,the control group was treated with conventional therapy ,and the observation group was treated with nimodip-ine tablets based on conventional therapy ,the cognitive function and cerebral blood flow changes were compared before and af-ter treatment .Results After treatment ,the MMSE and MoCA scores in the observation group were significantly improved compared with those before treatment ,and were significantly better than those of the control group ,the differences were statis-tically significant (P<0.05);MCA Vs ,MCA Vm of the bilateral middle cerebral artery were significantly higher than those before treatment (P<0.05) ,and PI was more obviously decreased than that before treatment (P<0.05). Conclusion The ni-modipine treatment in CCCI can dilate cerebral blood vessels ,and improve cerebral blood flow and cognitive function ,and it is safe.