中医临床研究
中醫臨床研究
중의림상연구
CLINICAL JOURNAL OF CHINESE MEDICINE
2014年
16期
130-132
,共3页
基底型偏头痛%偏头痛%高压氧%经颅多普勒
基底型偏頭痛%偏頭痛%高壓氧%經顱多普勒
기저형편두통%편두통%고압양%경로다보륵
Basilar migraine%Migraine%Hyperbaric oxygen%TCD
目的:采用高压氧治疗基底型偏头痛,观察其疗效并探讨其机理。方法:收集基底型偏头痛患者65例,采用随机数字表法将所收集的病例随机分为治疗组33例,对照组32例。治疗组治疗方案:采用密封式多人空气加压舱,治疗压力为0.2 MPa(2.0ATA),稳压65min,期间面罩吸纯氧30min×2,中间吸空气5min,降压25min,每日治疗1次。对照组予盐酸氟桂利嗪10mg每日晚睡前口服。通过一个疗程10d治疗,观察两组治疗效果。结果:(1)治疗前两组VAS、VRS及非疼痛时间无显著性差异(P>0.05),治疗后两组 VAS、VRS 均较治疗前明显降低(P<0.05),两组疗效相比,差异有显著意义(P<0.05)。两组治疗后非疼痛时间均较治疗前明显延长,并且治疗组(P<0.01)改善的程度比对照组(P<0.05)明显。(2)TCD检测结果显示,治疗前两组Vs、Vm、Vd、和PI无显著性差异(P>0.05);治疗后两组BA的Vs、Vm、Vd均有增加,并且治疗组(P<0.01)改善的程度比对照组(P<0.05)明显,治疗组 PI 明显下降;两组治疗后比较,差异具有明显统计学意义(P<0.01)。结论:两组治疗方法均能够显著改善基底型偏头痛患者发作时头痛程度及发作频度,改善患者基底动脉的血流速度及搏动指数,且高压氧治疗优于药物治疗。高压氧治疗基底型偏头痛有效,其机理之一可能为高压氧能够抑制炎性介质及血小板释放,增加基底动脉供血。
目的:採用高壓氧治療基底型偏頭痛,觀察其療效併探討其機理。方法:收集基底型偏頭痛患者65例,採用隨機數字錶法將所收集的病例隨機分為治療組33例,對照組32例。治療組治療方案:採用密封式多人空氣加壓艙,治療壓力為0.2 MPa(2.0ATA),穩壓65min,期間麵罩吸純氧30min×2,中間吸空氣5min,降壓25min,每日治療1次。對照組予鹽痠氟桂利嗪10mg每日晚睡前口服。通過一箇療程10d治療,觀察兩組治療效果。結果:(1)治療前兩組VAS、VRS及非疼痛時間無顯著性差異(P>0.05),治療後兩組 VAS、VRS 均較治療前明顯降低(P<0.05),兩組療效相比,差異有顯著意義(P<0.05)。兩組治療後非疼痛時間均較治療前明顯延長,併且治療組(P<0.01)改善的程度比對照組(P<0.05)明顯。(2)TCD檢測結果顯示,治療前兩組Vs、Vm、Vd、和PI無顯著性差異(P>0.05);治療後兩組BA的Vs、Vm、Vd均有增加,併且治療組(P<0.01)改善的程度比對照組(P<0.05)明顯,治療組 PI 明顯下降;兩組治療後比較,差異具有明顯統計學意義(P<0.01)。結論:兩組治療方法均能夠顯著改善基底型偏頭痛患者髮作時頭痛程度及髮作頻度,改善患者基底動脈的血流速度及搏動指數,且高壓氧治療優于藥物治療。高壓氧治療基底型偏頭痛有效,其機理之一可能為高壓氧能夠抑製炎性介質及血小闆釋放,增加基底動脈供血。
목적:채용고압양치료기저형편두통,관찰기료효병탐토기궤리。방법:수집기저형편두통환자65례,채용수궤수자표법장소수집적병례수궤분위치료조33례,대조조32례。치료조치료방안:채용밀봉식다인공기가압창,치료압력위0.2 MPa(2.0ATA),은압65min,기간면조흡순양30min×2,중간흡공기5min,강압25min,매일치료1차。대조조여염산불계리진10mg매일만수전구복。통과일개료정10d치료,관찰량조치료효과。결과:(1)치료전량조VAS、VRS급비동통시간무현저성차이(P>0.05),치료후량조 VAS、VRS 균교치료전명현강저(P<0.05),량조료효상비,차이유현저의의(P<0.05)。량조치료후비동통시간균교치료전명현연장,병차치료조(P<0.01)개선적정도비대조조(P<0.05)명현。(2)TCD검측결과현시,치료전량조Vs、Vm、Vd、화PI무현저성차이(P>0.05);치료후량조BA적Vs、Vm、Vd균유증가,병차치료조(P<0.01)개선적정도비대조조(P<0.05)명현,치료조 PI 명현하강;량조치료후비교,차이구유명현통계학의의(P<0.01)。결론:량조치료방법균능구현저개선기저형편두통환자발작시두통정도급발작빈도,개선환자기저동맥적혈류속도급박동지수,차고압양치료우우약물치료。고압양치료기저형편두통유효,기궤리지일가능위고압양능구억제염성개질급혈소판석방,증가기저동맥공혈。
Objective:To observe the curative effect and discuss the mechanism of hyperbaric oxygen on treating basilar migraine. Methods: 65 patients with basilar migraine were randomly divided into the treatment group (n=33) and the control group (n=32) by random number table. Patients in the treatment group were treated by sealed pressure cabin, 0.2 MPa(2.0ATA)for 65min, and mask absorbing pure oxygen for 30min×2, absorbing air for 5min and depressurization for 25min, once daily. Patients in the control group were given orally 10mg flunarizine hydrochloride before sleeping. The curative effects were compared for 10 days, a course of treatment. Results:I Before treatment, there was no significant difference in VAS, VRS and non-painful duration between the two groups (P>0.05); After treatment, VAS and VRS reduced obviously in the two groups (P<0.05), and the difference was significant (P<0.05). Non-painful duration was significantly extended, and it was clearer in the treatment group (P<0.01). Ⅱ By TCD examination, there was no significant difference in Vs, Vm, Vd and PI (P>0.05);After treatment, Vs, Vm and Vd increased in both, and it was clearer in the treatment group (P<0.01), and PI reduced obviously in the treatment group. The difference was significant (P<0.01). Conclusion:The treatments in both can markedly improve the extent and frequency of headache in patients with basilar migraine, and improve blood flow rate and pulsatility index, it showed that the curative effect of hyperbaric oxygen was better than medicine. Hyperbaric oxygen can inhibit inflammatory mediators and blood platelet releasing, increase basilar artery blood.