中医临床研究
中醫臨床研究
중의림상연구
CLINICAL JOURNAL OF CHINESE MEDICINE
2014年
16期
119-121
,共3页
益肾固摄汤%糖尿病肾病%中西医结合疗法
益腎固攝湯%糖尿病腎病%中西醫結閤療法
익신고섭탕%당뇨병신병%중서의결합요법
Yishen Gushe decoction%Diabetic nephropathy%The integrative medicine
目的：观察在西医的基础上使用中医益肾固摄汤治疗糖尿病肾病的疗效。方法：将58例患者随机分为对照组22例和治疗组36例，对照组为常规西医治疗，治疗组加上益肾固摄汤治疗，疗程8周。比较两组总疗效、24h尿蛋白定量、尿白蛋白排泄率（UAE）、血肌酐（Scr）、内生肌酐清除率（Ccr）、凝血酶原时间（PT）、血纤维蛋白（FIB）/血清总胆固醇（TC）、血清甘油三酯（TG）等指标变化。结果：治疗组总效率86.11%，明显高于对照组68.18%（P<0.05）；对照组尿蛋白及UAE明显减少，Scr下降明显，但Ccr无明显改善，对PT、FIB、TC、TG无明显影响。治疗组尿蛋白、UAE下降较对照组更明显，而且Ccr升高与对照组比较有统计学差异（P<0.05），治疗组PT延长，FIB、TC、TG明显下降，其中PT、TC、TG三者的变化与对照组比较有统计学差异（P<0.05）结论：益肾固摄汤结合西医治疗临床期糖尿病肾病疗效显著，可降低尿蛋白、UAE、Scr，提高Ccr，改善血脂和血液流变学。
目的：觀察在西醫的基礎上使用中醫益腎固攝湯治療糖尿病腎病的療效。方法：將58例患者隨機分為對照組22例和治療組36例，對照組為常規西醫治療，治療組加上益腎固攝湯治療，療程8週。比較兩組總療效、24h尿蛋白定量、尿白蛋白排洩率（UAE）、血肌酐（Scr）、內生肌酐清除率（Ccr）、凝血酶原時間（PT）、血纖維蛋白（FIB）/血清總膽固醇（TC）、血清甘油三酯（TG）等指標變化。結果：治療組總效率86.11%，明顯高于對照組68.18%（P<0.05）；對照組尿蛋白及UAE明顯減少，Scr下降明顯，但Ccr無明顯改善，對PT、FIB、TC、TG無明顯影響。治療組尿蛋白、UAE下降較對照組更明顯，而且Ccr升高與對照組比較有統計學差異（P<0.05），治療組PT延長，FIB、TC、TG明顯下降，其中PT、TC、TG三者的變化與對照組比較有統計學差異（P<0.05）結論：益腎固攝湯結閤西醫治療臨床期糖尿病腎病療效顯著，可降低尿蛋白、UAE、Scr，提高Ccr，改善血脂和血液流變學。
목적：관찰재서의적기출상사용중의익신고섭탕치료당뇨병신병적료효。방법：장58례환자수궤분위대조조22례화치료조36례，대조조위상규서의치료，치료조가상익신고섭탕치료，료정8주。비교량조총료효、24h뇨단백정량、뇨백단백배설솔（UAE）、혈기항（Scr）、내생기항청제솔（Ccr）、응혈매원시간（PT）、혈섬유단백（FIB）/혈청총담고순（TC）、혈청감유삼지（TG）등지표변화。결과：치료조총효솔86.11%，명현고우대조조68.18%（P<0.05）；대조조뇨단백급UAE명현감소，Scr하강명현，단Ccr무명현개선，대PT、FIB、TC、TG무명현영향。치료조뇨단백、UAE하강교대조조경명현，이차Ccr승고여대조조비교유통계학차이（P<0.05），치료조PT연장，FIB、TC、TG명현하강，기중PT、TC、TG삼자적변화여대조조비교유통계학차이（P<0.05）결론：익신고섭탕결합서의치료림상기당뇨병신병료효현저，가강저뇨단백、UAE、Scr，제고Ccr，개선혈지화혈액류변학。
Objective:To observe clinical effects of Yishen Gushe decoction on treating diabetic nephropathy. Methods:58 patients were divided into the control of 22 cases and the treatment of 36 cases, the control was treated by routine western medicine while the treatment was given Yishen Gushe more. The total efficacy, 24h urinary protein, UAE, Scr, Ccr, PT, FIB/ TC, TG in two groups were recorded and observed. Results: The total efficacy of 86.11% in the treatment was better than that in the control of 68.18% (P<0.05);urinary protein and UAE in the control was obvious decrease, the situation was the same as Scr, Ccr has no obvious improvement, PT, FIB, TC, TG were not influenced. The decrease of urinary protein and UAE in the treatment was more obvious, the higher Ccr has a statistically difference compared with that in the control (P<0.05), PT in the treatment extended, FIB, TC, TG decreased and the change of PT, TC, TG shows a statically difference compared with that in the control (P<0.05). Conclusion: Yishen Gushe decoction combined with western medicine has good effects and can decrease urinary protein, UAE, Scr, improve Ccr and Lipid and blood rheology.
