CAJ | 학술논문

目的：通过临床观察，分析黄连温胆汤治疗抗生素上消化道反应的安全性与有效性，为临床上应用中医药治疗抗生素导致上消化道副作用提供可靠证据，推动中医药在抗生素毒副作用治疗方面的应用。方法：抽取我院内科因使用抗生素1～3d内导致脘痞、纳差、胃痛等上消化道症状的湿热中阻型病例80例，随机分为试验组40例，对照组40例进行治疗。试验组患者给予黄连温胆汤加减内服治疗，对照组给予常规西药治疗。结果：在患者脘痞、纳差、胃痛等症状改善程度和改善时间上两组无明显差异，但治疗组患者舌苔黄腻，口中黏腻不爽等指标的改善明显优于对照组。结论：在抗生素所致上消化道反应（纳差、脘痞、胃痛等）的治疗中，中医药早期干预治疗的综合效果明显优于西药的对症处理治疗，值得临床大力推广应用。
목적：통과림상관찰，분석황련온담탕치료항생소상소화도반응적안전성여유효성，위림상상응용중의약치료항생소도치상소화도부작용제공가고증거，추동중의약재항생소독부작용치료방면적응용。방법：추취아원내과인사용항생소1～3d내도치완비、납차、위통등상소화도증상적습열중조형병례80례，수궤분위시험조40례，대조조40례진행치료。시험조환자급여황련온담탕가감내복치료，대조조급여상규서약치료。결과：재환자완비、납차、위통등증상개선정도화개선시간상량조무명현차이，단치료조환자설태황니，구중점니불상등지표적개선명현우우대조조。결론：재항생소소치상소화도반응（납차、완비、위통등）적치료중，중의약조기간예치료적종합효과명현우우서약적대증처리치료，치득림상대력추엄응용。
Objective: According to clinical observation, safety and effectiveness of Huanglian Wendan decoction for upper gastrointestinal reactions of antibiotic were analyzed, to provide reliable TCM treatment and promote the application of TCM. Methods:80 patients were randomly divided into test group and control group, 40 cases for each. Test group was given Huanglian Wendan decoction, control group was given conventional medicine. Results: The degree of improvement and improving time of clinical symptoms (Wanpi, Nacha, stomach pain) had not obvious different;but the index of Shetai Huangni and sticky mouth in test group was better than that in the control. Conclusion:On treating upper gastrointestinal reactions of antibiotic, early intervention of TCM has more obvious efficacy than Western medicine, was worthy of clinical application.