CAJ | 학술논문

目的：研究威灵仙注射液关节腔离子导入对OA的软骨和滑膜组织形态和软骨MMP-1细胞凋亡的影响。方法：新西兰兔40只，除保留10只作为正常组外，余均采用木瓜蛋白酶关节腔注射复制OA模型。造模4周后，根据模型动物关节肿胀度随机分为模型组、Wlx组、Qand组。实验结束时，取模型动物关节软骨和滑膜进行病理形态学检查，同时观察软骨细胞凋亡情况。结果：威灵仙关节腔离子导入能明显降低模型动物关节软骨和滑膜的病理总积分，同时亦能明显降低软骨 MMP-1细胞的阳性表达率。结论：威灵仙关节腔离子导入可能具有抑制骨关节炎的软骨退行性改变的作用，能够延缓OA的炎症进程。
목적：연구위령선주사액관절강리자도입대OA적연골화활막조직형태화연골MMP-1세포조망적영향。방법：신서란토40지，제보류10지작위정상조외，여균채용목과단백매관절강주사복제OA모형。조모4주후，근거모형동물관절종창도수궤분위모형조、Wlx조、Qand조。실험결속시，취모형동물관절연골화활막진행병리형태학검사，동시관찰연골세포조망정황。결과：위령선관절강리자도입능명현강저모형동물관절연골화활막적병리총적분，동시역능명현강저연골 MMP-1세포적양성표체솔。결론：위령선관절강리자도입가능구유억제골관절염적연골퇴행성개변적작용，능구연완OA적염증진정。
Objective:To study effects of Clematis chinensis injection on OA cartilage and synovial membrane tissue morphology and apoptosis of MMP-1 cell with articular cavity iontophoresis. Methods:40 New Zealand rabbits, except 10 rabbits as normal group, the others were used to replicate OA model by papain intra-articular injection. After 4 weeks modeling, according to the degree of joint swelling, model animals were randomly divided into model group, Wlx group, Qand group. At the end of the experiment, examinated pathological total points of articular cartilage and synovium membrane, the cartilage cell apoptosis was observed. Results:Clematis articular iontophoresis can significantly reduce articular cartilage and synovial pathological score of model animals, but also can significantly reduce the positive expression rate of MMP-1 cell of cartilage. Conclusion: Clematis articular iontophoresis may inhibit osteoarthritis cartilage degeneration, can slow down the inflammatory process of OA.