中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
19期
73-75,76
,共4页
2型糖尿病%牙周炎%IL-6%ELISA
2型糖尿病%牙週炎%IL-6%ELISA
2형당뇨병%아주염%IL-6%ELISA
Diabetes mellitus%Periodontitis%IL-6%ELISA
目的：探讨牙周炎对2型糖尿病患者血清和龈沟液IL-6含量的影响。方法：采用酶联免疫吸附试验（ELISA）检测20例2型糖尿病伴牙周炎患者、20例单纯2型糖尿病患者、20例单纯牙周炎患者及16例健康者的血清和龈沟液（GCF）中IL-6含量，比较组间血清和龈沟液IL-6含量的差异性，分析组内血清和龈沟液IL-6含量的相关性。结果：2型糖尿病伴牙周炎组、单纯2型糖尿病组及单纯牙周炎组的IL-6含量均明显高于健康组（P<0.001），且2型糖尿病伴牙周炎组高于单纯糖尿病组及单纯牙周炎组；血清和龈沟液IL-6含量在伴牙周炎糖尿病组（r=0.829，P<0.001）、单纯2型糖尿病组（r=0.766，P<0.001）及单纯牙周炎组（r=0.732， P<0.01）均呈正相关关系。结论：牙周炎可提高2型糖尿病患者血清和龈沟液IL-6的含量，IL-6可能在牙周炎与糖尿病之间的双向作用中具有重要意义。
目的：探討牙週炎對2型糖尿病患者血清和齦溝液IL-6含量的影響。方法：採用酶聯免疫吸附試驗（ELISA）檢測20例2型糖尿病伴牙週炎患者、20例單純2型糖尿病患者、20例單純牙週炎患者及16例健康者的血清和齦溝液（GCF）中IL-6含量，比較組間血清和齦溝液IL-6含量的差異性，分析組內血清和齦溝液IL-6含量的相關性。結果：2型糖尿病伴牙週炎組、單純2型糖尿病組及單純牙週炎組的IL-6含量均明顯高于健康組（P<0.001），且2型糖尿病伴牙週炎組高于單純糖尿病組及單純牙週炎組；血清和齦溝液IL-6含量在伴牙週炎糖尿病組（r=0.829，P<0.001）、單純2型糖尿病組（r=0.766，P<0.001）及單純牙週炎組（r=0.732， P<0.01）均呈正相關關繫。結論：牙週炎可提高2型糖尿病患者血清和齦溝液IL-6的含量，IL-6可能在牙週炎與糖尿病之間的雙嚮作用中具有重要意義。
목적：탐토아주염대2형당뇨병환자혈청화간구액IL-6함량적영향。방법：채용매련면역흡부시험（ELISA）검측20례2형당뇨병반아주염환자、20례단순2형당뇨병환자、20례단순아주염환자급16례건강자적혈청화간구액（GCF）중IL-6함량，비교조간혈청화간구액IL-6함량적차이성，분석조내혈청화간구액IL-6함량적상관성。결과：2형당뇨병반아주염조、단순2형당뇨병조급단순아주염조적IL-6함량균명현고우건강조（P<0.001），차2형당뇨병반아주염조고우단순당뇨병조급단순아주염조；혈청화간구액IL-6함량재반아주염당뇨병조（r=0.829，P<0.001）、단순2형당뇨병조（r=0.766，P<0.001）급단순아주염조（r=0.732， P<0.01）균정정상관관계。결론：아주염가제고2형당뇨병환자혈청화간구액IL-6적함량，IL-6가능재아주염여당뇨병지간적쌍향작용중구유중요의의。
Objective: To detect the effect of Periodontitis on the concentration of IL-6 in serum and gingival crevicular fluid in type 2 diabetic patients.Method: Twenty patients with type-2 diabetes and periodontitis, 20 with simple type-2 diabetes, 20 with simple periodontitis and 16 healthy patients were recruited in this study. The concentration of IL-6 in serum and gingival crevicular fluid were detected by Enzyme Linked Immunosorbent Assay (ELISA), the difference of IL-6 content in serum and gingival crevicular fluid were compared among groups, the correlation between the concentration of IL-6 in serum and that in gingival crevicular fluid were analyzed within group.Result: The concentration of IL-6 in serum and gingival crevicular fluid in three unhealthy groups were significantly higher than that in the healthy group (P<0.001).The concentration of IL-6 in serum and gingival crevicular fluid of the patients with type-2 diabetes and periodontitis were higher than that of the patients just with diabetes or periodontitis. There was a positive correlation between the concentration of IL-6 in serum and that in gingival crevicular fluid respectively in type-2 diabetes patients with periodontitis group (r=0.829,P<0.01), simple diabetes mellitus group (r=0.766,P<0.01) and simple periodontitis group (r=0.732,P<0.01).Conclusion: The concentration of IL-6 in serum and gingival crevicular fluid in type-2 diabetes patients can be increased by periodontitis, IL-6 may play an important role in the interaction between periodontal disease and diabetes.
