CAJ | 학술논문

目的：探讨急性冠脉综合征（ACS）患者血浆D-二聚体和心肌标志物的水平及临床应用价值。方法：对200例ACS患者，其中不稳定型心绞痛（UAP）85例、非ST段抬高型心肌梗死（NSTEMI）59例、ST段抬高型心肌梗死（STEMI）56例的血浆D-二聚体和几种心肌标志物进行检测，并与同时选取的50例正常对照者进行比较。其中D-二聚体由法国Stago-STA-R全自动血凝仪完成；以双向测流免疫法检测患者心肌肌钙蛋白I（cTnI）、肌红蛋白（Myoglobin）、肌酸激酶同工酶（CK-MB）。结果：UAP组的D-二聚体水平为（11.6±7.3）mg/L、cTnI（0.24±0.15）ng/mL、CK-MB（16.3±7.3）ng/mL、Myoglobin（160.6±42.1）ng/mL；NSTEMI组分别为（13.9±6.7）mg/L、（0.38±0.35）ng/mL、（21.3±16.9）ng/mL、（183.4±48.9）ng/mL；STEMI组分别为（19.2±6.9）mg/L、（5.30±3.61）ng/mL、（50.3±18.6）ng/mL、（238.3±58.6）ng/mL。三组的血浆D-二聚体和几种心肌标志物的水平与正常对照组比较差异均有统计学意义（P<0.01）；STEMI组各指标水平与UAP组、NSTEMI组比较差异均有统计学意义（P<0.05）。结论：患者血浆D-二聚体和几种心肌标志物在辅助诊断UAP、NSTEMI、STEMI时具有重要的参考价值。
목적：탐토급성관맥종합정（ACS）환자혈장D-이취체화심기표지물적수평급림상응용개치。방법：대200례ACS환자，기중불은정형심교통（UAP）85례、비ST단태고형심기경사（NSTEMI）59례、ST단태고형심기경사（STEMI）56례적혈장D-이취체화궤충심기표지물진행검측，병여동시선취적50례정상대조자진행비교。기중D-이취체유법국Stago-STA-R전자동혈응의완성；이쌍향측류면역법검측환자심기기개단백I（cTnI）、기홍단백（Myoglobin）、기산격매동공매（CK-MB）。결과：UAP조적D-이취체수평위（11.6±7.3）mg/L、cTnI（0.24±0.15）ng/mL、CK-MB（16.3±7.3）ng/mL、Myoglobin（160.6±42.1）ng/mL；NSTEMI조분별위（13.9±6.7）mg/L、（0.38±0.35）ng/mL、（21.3±16.9）ng/mL、（183.4±48.9）ng/mL；STEMI조분별위（19.2±6.9）mg/L、（5.30±3.61）ng/mL、（50.3±18.6）ng/mL、（238.3±58.6）ng/mL。삼조적혈장D-이취체화궤충심기표지물적수평여정상대조조비교차이균유통계학의의（P<0.01）；STEMI조각지표수평여UAP조、NSTEMI조비교차이균유통계학의의（P<0.05）。결론：환자혈장D-이취체화궤충심기표지물재보조진단UAP、NSTEMI、STEMI시구유중요적삼고개치。
Objective:To investigate the clinical application value of the levels of D -D and cardiac biomarkers and in patients with acute coronary syndrome (ACS).Method: 200 patients with acute coronary syndrome were selected, and included stable angina pectoris (UAP) patients 85 cases, non st-elevation myocardial infarction (NSTEMI) patients 59 cases, ST segment elevation myocardial infarction (STEMI) patients 56 cases. Their plasma D-D and cardiac biomarkers were detected,and compared with the normal control who were selected at the same time. D-D was detected by the French Stago-STA-R automatic blood coagulation analyzer, cTnI, Myoglobin, CK-MB were detected with bidirectional lateral flow immunoassay.Result: The UAP group: D-D was (11.6±7.3)mg/L, cTnI was (0.24±0.15)ng/mL, CK-MB was (16.3±7.3)ng/mL, Myoglobin was (160.6±42.1)ng/mL; the NSTEMI group respectively were (13.9±6.7)mg/L, (0.38±0.35)ng/mL, (21.3±16.9)ng/mL, (183.4±48.9)ng/mL;the STEMI group respectively were (19.2±6.9)mg/L, (5.30±3.61)ng/mL, (50.3±18.6)ng/mL, (238.3±58.6)ng/mL. The levels of plasma D-D and cardiac biomarkers in the patients with the three groups were compared with the normal control group, had a significant different(P<0.01); the levels of above indexs in the STEMI group compared with the other groups, the differences were statistically significant (P<0.05).Conclusion:Plasma D-D and cardiac biomarkers has important reference value in the auxiliary diagnosis for the patients with UAP, NSTEMI, STEMI.