CAJ | 학술논문

目的：探讨危重病患者可溶性髓样细胞表达的触发受体-1（sTREM-1）与炎症因子表达的相关性及对疾病严重程度的评估作用和预后的影响。方法对入住该院 ICU 的54例危重病患者分别于第1天采血检测 sTREM-1、肿瘤坏死因子-α（TNF-α）、IL-6、IL-10的表达水平，第3天重复检测sTREM-1的表达水平，同时记录急性生理学与慢性健康状况评分（APACHEⅡ评分）及患者28 d生存情况。结果危重病患者sTREM-1的表达水平与 TNF-α、IL-6的表达水平及APACHEⅡ评分呈正相关（P＜0．01），TNF-α、IL-6的表达水平也与APACHEⅡ评分呈正相关，但这两个指标的pearson相关系数明显低于sTREM-1。死亡组中两次的sTREM-1的表达水平均明显高于非死亡组（P＜0．05）。结论 sTREM-1的表达水平与炎症反应及疾病严重程度呈正相关，且sTREM-1的表达水平可作为判断预后的指标。
목적：탐토위중병환자가용성수양세포표체적촉발수체-1（sTREM-1）여염증인자표체적상관성급대질병엄중정도적평고작용화예후적영향。방법대입주해원 ICU 적54례위중병환자분별우제1천채혈검측 sTREM-1、종류배사인자-α（TNF-α）、IL-6、IL-10적표체수평，제3천중복검측sTREM-1적표체수평，동시기록급성생이학여만성건강상황평분（APACHEⅡ평분）급환자28 d생존정황。결과위중병환자sTREM-1적표체수평여 TNF-α、IL-6적표체수평급APACHEⅡ평분정정상관（P＜0．01），TNF-α、IL-6적표체수평야여APACHEⅡ평분정정상관，단저량개지표적pearson상관계수명현저우sTREM-1。사망조중량차적sTREM-1적표체수평균명현고우비사망조（P＜0．05）。결론 sTREM-1적표체수평여염증반응급질병엄중정도정정상관，차sTREM-1적표체수평가작위판단예후적지표。
Objective To investigate the correlation between sTREM-1 and inflammatory factors expression in critical patients and its effect on severity of disease and clinical prognosis .Methods sTREM-1 ,TNF-α,IL-6 ,IL-10 levels were checked in serum of 54 patients who admitted to intensive care unit (ICU) on the first day and only sTREM-1 was checked again on the third day .At the same time ,APACHEⅡand survival situation in 28 days were recorded .Results sTREM-1 level in critical patients was positive correlated with TNF-α,IL-6 and APACHEⅡ(P<0 .01) .There was positive correlation between APACHE Ⅱ and TNF-α,IL-6 ,but pearson correlation coefficient between sTREM-1 and APACHE Ⅱ was higher than TNF-α,IL-6 .Compared with the survivor group ,the concentrations of serum sTREM-1 was significantly higer in non-survivor group on the first day and the third day after entering ICU(P<0 .05) .Conclusion sTREM-1 level is positive correlated with inflammatory reaction and the severity of disease .It also has prognostic value for outcome in patients with critical illness .