CAJ | 학술논문

目的：探讨血清血清胱抑素C（Cys C）和同型半胱氨酸（Hcy）水平在2型糖尿病肾病不同肾损害期的应用价值。方法收集我院内2013年1月-2013年10月住院的2型糖尿病患者128例，根据24 h尿白蛋白排泄率(UAER)的不同分为第一组、第二组和第三组，并选择同期健康体检者80例作为正常对照组，分别检测血清肌酐（Cr）、尿素氮（BUN）、Cys C和Hcy水平，并对检测结果进行统计分析。结果单纯2型糖尿病组、早期糖尿病肾病组、临床糖尿病肾病组血清Cys C、Hcy水平分别为（0.73±0.25）、（1.43±0.41）、（2.05±0.59）mg/L和（9.8±2.1）、（15.6±4.6）、（36.4±6.2）μmol/L，与对照组（0.13±0.05） mg/L和（2.80±1.10）μmol/L相比有明显差异，差异有统计学意义（P<0.05），UAER与血清CysC水平呈正相关(r=0.571,P<0.05)，与Hcy水平呈正相关（r=0.34,P<0.05）。结论联合检测血清血清Cys C、Hcy对早期DN的诊断、以及评估糖尿病肾损伤程度具有重要意义。
목적：탐토혈청혈청광억소C（Cys C）화동형반광안산（Hcy）수평재2형당뇨병신병불동신손해기적응용개치。방법수집아원내2013년1월-2013년10월주원적2형당뇨병환자128례，근거24 h뇨백단백배설솔(UAER)적불동분위제일조、제이조화제삼조，병선택동기건강체검자80례작위정상대조조，분별검측혈청기항（Cr）、뇨소담（BUN）、Cys C화Hcy수평，병대검측결과진행통계분석。결과단순2형당뇨병조、조기당뇨병신병조、림상당뇨병신병조혈청Cys C、Hcy수평분별위（0.73±0.25）、（1.43±0.41）、（2.05±0.59）mg/L화（9.8±2.1）、（15.6±4.6）、（36.4±6.2）μmol/L，여대조조（0.13±0.05） mg/L화（2.80±1.10）μmol/L상비유명현차이，차이유통계학의의（P<0.05），UAER여혈청CysC수평정정상관(r=0.571,P<0.05)，여Hcy수평정정상관（r=0.34,P<0.05）。결론연합검측혈청혈청Cys C、Hcy대조기DN적진단、이급평고당뇨병신손상정도구유중요의의。
Objective To investigate the value of serum cystatin C(Cys C) and Homocysteine(Hcy) in different stage of renal dam-age in type 2 diabetes (T2DM). Methods A total of 128 patients with T2DM were recruited from January 2013 to October 2013, According to 24h urinary albumin excretion rate (UAER) were divided into the first group, the second and third groups, and choose 80 healthy cases over the same period as the normal control group. Serum Cys C、Hcy 、creatinine (Cr) and blood urea ni-trogen (BUN) were detected , the test results were analyzed statistically.Results The levels of serum Cys C, Hcy levels were(0.73± 0.25)、(1.43±0.41)、(2.05±0.59)mg/L and (9.8±2.1)、(15.6±4.6)、(36.4±6.2)μmol/L,there are significant differences comparared to the control group(0.13±0.05) mg/L and (2.80±1.10)μmol/L(P<0.05), there are positively correlated (r=0.571,P<0.05) between UAER and serum CysC levels, and are positively correlated (r= 0.34, P<0.05) between UAER and Hcy levels. Conclusion Com-bined detection of serum Cys C, Hcy have a significance for early diagnosis of Diabetic nephropathy and assessing the degree of renal injury in diabetes.