CAJ | 학술논문

目的：分析拉米夫定与阿德福韦酯治疗乙型肝炎肝硬化患者的临床疗效。方法患者入院治疗后均给予对症治疗、护肝及保肝等常规治疗，采用拉米夫定治疗A组患者，剂量为100 mg/d；采用阿德福韦酯治疗B组患者，剂量为10mg/d；联合应用阿德福韦酯与拉米夫定治疗C组患者，拉米夫定剂量为100 mg/d，阿德福韦酯为10mg/d。结果 C组HBV DNA 水平与A组及B组相比存在显著性差异（P<0.05）；C组HBV DNA的转阴率也明显高于A组及B组，且存在显著性差异（P<0.05）。 C组的肝功能明显优于A组及B组（P<0.05）。结论联合阿德福韦酯与拉米夫定治疗肝硬化的临床疗效显著，可推广应用。
목적：분석랍미부정여아덕복위지치료을형간염간경화환자적림상료효。방법환자입원치료후균급여대증치료、호간급보간등상규치료，채용랍미부정치료A조환자，제량위100 mg/d；채용아덕복위지치료B조환자，제량위10mg/d；연합응용아덕복위지여랍미부정치료C조환자，랍미부정제량위100 mg/d，아덕복위지위10mg/d。결과 C조HBV DNA 수평여A조급B조상비존재현저성차이（P<0.05）；C조HBV DNA적전음솔야명현고우A조급B조，차존재현저성차이（P<0.05）。 C조적간공능명현우우A조급B조（P<0.05）。결론연합아덕복위지여랍미부정치료간경화적림상료효현저，가추엄응용。
Objective To analyze the clinical efficacy in patients with lamivudine and adefovir dipivoxil in the treatment of hep-atitis B cirrhosis. Patients were given symptomatic treatment, liver and liver and other conventional treatment. Methods In patients after treatment, A group were treated with lamivudine treatment, a dose of 100mg/d; with adefovir dipivoxil in the treatment of pa-tients in the B group, the dose of 10mg/d; the application of adefovir and lamivudine in the treatment of C patients with lamivu-dine, adefovir dose of 100mg/d, 10mg/d. Results In group C, HBV and DNA level of A group and B group compared to the exis-tence of significant differences (P<0.05); group C HBV DNA negative rate were significantly higher than those in A group and B group, and the difference was significant (P<0.05). C group of liver function was better than that in A group and B group (P<0.05). Conclusion The curative effect of combined with adefovir and lamivudine in treatment of liver cirrhosis was significantly, can be applied.