CAJ | 학술논문

分泌型卷曲相关蛋白（SFRP）5是SFRP家族中的一员，是一种新型的抗炎脂肪因子。已有研究表明， SFRP5的表达与糖尿病、肥胖相关，其可竞争性结合Wnt信号通路胞外配体Wnt5a蛋白，从而抑制Wnt信号通路，改善胰岛素抵抗，调节糖脂代谢。本文对SFRP5与肥胖及糖尿病的相关性研究成果进行综述，为今后提高对2型糖尿病的诊治提供思路。
분비형권곡상관단백（SFRP）5시SFRP가족중적일원，시일충신형적항염지방인자。이유연구표명， SFRP5적표체여당뇨병、비반상관，기가경쟁성결합Wnt신호통로포외배체Wnt5a단백，종이억제Wnt신호통로，개선이도소저항，조절당지대사。본문대SFRP5여비반급당뇨병적상관성연구성과진행종술，위금후제고대2형당뇨병적진치제공사로。
Secretedfrizzled-relatedprotein5(SRPF5),amemberofSRPFfamily,isanovelanti-inflammatory adipokine. Studies have shown that SFRP5 is associated with diabetes and obesity and can competitively bind Wnt5a protein which is one of Wnt signaling pathway extracellular ligands,inhibit the Wnt signaling pathway,reduce insulin resistance,and regulate the glucolipid metabolism. This paper reviews the relationship of SFRP5 to obesity and diabetes,to provide a new train of thought for T2Dm diagnosis and treatment.