CAJ | 학술논문

目的探讨脐血间充质干细胞移植治疗失代偿期肝硬化的临床疗效。方法选择2009年8月-2011年2月在郑州大学附属郑州市中心医院就诊的失代偿期肝硬化患者46例，采用随机数字表法分为治疗组24例，对照组22例。对照组患者给予常规治疗，治疗组在常规治疗基础上加用脐血间充质干细胞移植治疗。观察两组患者治疗前，治疗1、2、4、8、12周时血浆清蛋白、前清蛋白、总胆红素水平变化及不良反应发生情况，并于治疗前、治疗12周时对治疗组患者进行SF-36量表（中文版）评分。结果两组患者治疗前，治疗1、2周时血浆清蛋白、前清蛋白水平比较，差异均无统计学意义（ P﹥0.05）；治疗组治疗4、8、12周时血浆清蛋白、前清蛋白水平高于对照组（ P﹤0.05）；两组患者治疗前，治疗2、4、8、12周时总胆红素水平比较，差异均无统计学意义（P﹥0.05）；治疗组治疗1周时总胆红素水平高于对照组（ P﹤0.05）。治疗组患者治疗后躯体功能、肢体疼痛、总的健康状况、活力、社会功能、心理健康领域评分均高于治疗前（ P﹤0.05），且均有临床和统计学意义；而躯体角色、情绪角色评分治疗前后比较，差异均无统计学意义（P﹥0.05），亦无临床和社会意义。两组患者均未出现皮疹、恶心、出血、感染等不良反应。结论脐血间充质干细胞移植治疗失代偿期肝硬化安全有效，能有效改善患者肝功能和生活质量，延缓其病程进展。
목적탐토제혈간충질간세포이식치료실대상기간경화적림상료효。방법선택2009년8월-2011년2월재정주대학부속정주시중심의원취진적실대상기간경화환자46례，채용수궤수자표법분위치료조24례，대조조22례。대조조환자급여상규치료，치료조재상규치료기출상가용제혈간충질간세포이식치료。관찰량조환자치료전，치료1、2、4、8、12주시혈장청단백、전청단백、총담홍소수평변화급불량반응발생정황，병우치료전、치료12주시대치료조환자진행SF-36량표（중문판）평분。결과량조환자치료전，치료1、2주시혈장청단백、전청단백수평비교，차이균무통계학의의（ P﹥0.05）；치료조치료4、8、12주시혈장청단백、전청단백수평고우대조조（ P﹤0.05）；량조환자치료전，치료2、4、8、12주시총담홍소수평비교，차이균무통계학의의（P﹥0.05）；치료조치료1주시총담홍소수평고우대조조（ P﹤0.05）。치료조환자치료후구체공능、지체동통、총적건강상황、활력、사회공능、심리건강영역평분균고우치료전（ P﹤0.05），차균유림상화통계학의의；이구체각색、정서각색평분치료전후비교，차이균무통계학의의（P﹥0.05），역무림상화사회의의。량조환자균미출현피진、악심、출혈、감염등불량반응。결론제혈간충질간세포이식치료실대상기간경화안전유효，능유효개선환자간공능화생활질량，연완기병정진전。
Objective Toinvestigatetheclinicaleffectsofhumanumbilicalcordblood(UCB)mesenchymalstem cell(mSCs)transplantationintreatmentofdecompensatedlivercirrhosis(DLC).Methods Twenty-sixDLCpatientsad-mitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University hospital from August 2009 to February 2011 were divided randomly into groups study(n=24),control(n=22). The control group were given conventional therapy,study group given additional UCB mSCs transplantation. The plasma albumin(ALB),prealbumin(PAB),total bilirubin(TBiL)and adverse reactions were observed before treatment and after 1,2,4,8,12 weeks of treatment,and the study group scored by SF-36 Scale(Chineseversion)beforetreatmentandafter12weeksoftreatment.Results TherewasnosignificantdifferenceinALB, PAB levels between 2 groups before treatment and after 1,2 weeks of treatment(P﹥0. 05),and higher in study group than in control group after 4,8,12 weeks of treatment(P﹤0. 05). There was no significant difference in TBiL level between 2 groups before treatment and after 2,4,8 12 weeks of treatment(P﹥0. 05),higher in study group than in control group after 1 week of treatment(P﹤0. 05). The scores of physical function,limb pain,general health,vitality,social function,mental health in study group were higher after treatment than before(P﹤0. 05),but there was no significant difference in physical role,emo-tional role between pre- and post-treatment(P﹥0. 05). Both groups had not rash,nausea,bleeding,infection and other adversereactions.Conclusion UCBmSCstransplantation,safeandeffectiveintreatmentofDLC,caneffectivelyimprovepa-tients′liver function and quality of life and delay its progression.