中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2014年
20期
84-86
,共3页
原发性肝细胞癌%肿瘤抑制素M%受体%临床资料%表达
原髮性肝細胞癌%腫瘤抑製素M%受體%臨床資料%錶達
원발성간세포암%종류억제소M%수체%림상자료%표체
HCC%OSM%OSMR%Clinical data%Expression
目的：探讨原发性肝癌（HCC）及癌旁组织中OSM、 OSMR表达与临床资料的关系及意义。方法用固相夹心法酶联免疫吸附法（ELISA）检测30例HCC及其癌旁组织中OSM、OSMR表达水平，常规检测患者术前血清AFP、AST、ALT、TBIL水平，并同时将30例肝癌患者按性别、年龄、Child分级、AFP、乙型肝炎表面抗原、肝硬化、TNM分期、肿瘤有无假包膜情况进行分组，通过方差分析与Logistic回归对肝癌及癌旁组织OSM、OSMR表达与以上临床资料进行分析，研究原发性肝细胞癌中OSM OSMR表达与临床资料关系及意义。结果①肝癌及癌旁组织中OSM、OSMR表达与年龄、性别、乙型肝炎表面抗原阳性、Child分级、肝硬化、AST、ALT、TBIL等因素无关（P>0.05）；②肝癌及癌旁组织中OSM、OSMR表达与AFP、TNM分期、肿瘤有无假包膜相关（P<0.05）。结论 OSM、OSMR与HCC发生、发展密切相关；肝癌及癌旁组织中OSM、OSMR表达与AFP、TNM分期、肿瘤无假包膜密切相关。
目的：探討原髮性肝癌（HCC）及癌徬組織中OSM、 OSMR錶達與臨床資料的關繫及意義。方法用固相夾心法酶聯免疫吸附法（ELISA）檢測30例HCC及其癌徬組織中OSM、OSMR錶達水平，常規檢測患者術前血清AFP、AST、ALT、TBIL水平，併同時將30例肝癌患者按性彆、年齡、Child分級、AFP、乙型肝炎錶麵抗原、肝硬化、TNM分期、腫瘤有無假包膜情況進行分組，通過方差分析與Logistic迴歸對肝癌及癌徬組織OSM、OSMR錶達與以上臨床資料進行分析，研究原髮性肝細胞癌中OSM OSMR錶達與臨床資料關繫及意義。結果①肝癌及癌徬組織中OSM、OSMR錶達與年齡、性彆、乙型肝炎錶麵抗原暘性、Child分級、肝硬化、AST、ALT、TBIL等因素無關（P>0.05）；②肝癌及癌徬組織中OSM、OSMR錶達與AFP、TNM分期、腫瘤有無假包膜相關（P<0.05）。結論 OSM、OSMR與HCC髮生、髮展密切相關；肝癌及癌徬組織中OSM、OSMR錶達與AFP、TNM分期、腫瘤無假包膜密切相關。
목적：탐토원발성간암（HCC）급암방조직중OSM、 OSMR표체여림상자료적관계급의의。방법용고상협심법매련면역흡부법（ELISA）검측30례HCC급기암방조직중OSM、OSMR표체수평，상규검측환자술전혈청AFP、AST、ALT、TBIL수평，병동시장30례간암환자안성별、년령、Child분급、AFP、을형간염표면항원、간경화、TNM분기、종류유무가포막정황진행분조，통과방차분석여Logistic회귀대간암급암방조직OSM、OSMR표체여이상림상자료진행분석，연구원발성간세포암중OSM OSMR표체여림상자료관계급의의。결과①간암급암방조직중OSM、OSMR표체여년령、성별、을형간염표면항원양성、Child분급、간경화、AST、ALT、TBIL등인소무관（P>0.05）；②간암급암방조직중OSM、OSMR표체여AFP、TNM분기、종류유무가포막상관（P<0.05）。결론 OSM、OSMR여HCC발생、발전밀절상관；간암급암방조직중OSM、OSMR표체여AFP、TNM분기、종류무가포막밀절상관。
ObjectiveTo resarech the expression of oncostatin M and its receptor in hepatocellular carcinoma tissues,tissues surrounding hepatoma and the relationship between clinical data, to explore possiblely mechanisms and signiifcance by which they affect hepatocellular carcinoma.MethodsELISA immunohistochemistry and ELISA absorbance method was used to detect the expression of oncostatin M and its receptor in hepatocellular carcinoma tissues and tissues surrounding hepatoma in 30 patients with corroborative HCC thyough pathology , 5 normal liver tissue and 6 cases tissue of Hemangiomas. Routinely testing the level of AFP, AST, ALT, TBIL in patients with preoperative serum, distinguishing different groups by sex, age, Child classiifcation, AFP, HBsAg, liver cirrhosis, TNM stage, tumor pseudocapsule situation whether in 30 cases patients with HCC. Analysised the relationship between clinical data and oncostatin M and its receptor in hepatocellular carcinoma tissues,tissues surrounding hepatoma by variance analysis and Logistic regression, to resarech expression and effects of oncostatin M and its receptor in hepatocellular carcinoma tissues and the relationship between clinical data.Results①The expression of OSM and OSMR in hepatocellular carcinoma tissues and tissues surrounding hepatoma are unrelated with the groups of sex, age, Child classiifcation, HBsAg, liver cirrhosis in patients with HCC(P>0.05).②The expression of OSM and OSMR in hepatocellular carcinoma tissues and tissues surrounding hepatoma are interrelated with the AFP,TNM stage, tumor pseudocapsule situation whether in patients with HCC(P<0.05).Conclusion①The expression of oncostatin M and its receptor in hepatocellular carcinoma is very important to intffer the occurrence and progress of HCC.②The expression of OSM and OSMR in hepatocellular carcinoma tissues and tissues surrounding hepatoma are closely interrelated with the AFP,TNM stage, tumor pseudocapsule situation whether in patients with HCC.
