CAJ | 학술논문

目的：研究Fas-670基因多态性与青海地区乳腺癌临床病理指标的关系。方法采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析方法，检测了232例青海女性乳腺癌患者Fas-670基因多态性，用χ2检验分析其基因多态性与乳腺癌临床病理指标间的关系。结果232例乳腺癌中，Fas-670基因多态频率分布：纯合野生型AA为39．7％（92/232）、杂合型AG为48．7％（113/232）、纯合突变型GG为11．6％（27/232）。Fas-670基因型与青海乳腺癌临床病理指标无相关性（P＞0．05）。结论Fas-670基因多态性与青海地区乳腺癌临床病理指标无联系。
목적：연구Fas-670기인다태성여청해지구유선암림상병리지표적관계。방법채용취합매련반응-한제성편단장도다태성（PCR-RFLP）분석방법，검측료232례청해녀성유선암환자Fas-670기인다태성，용χ2검험분석기기인다태성여유선암림상병리지표간적관계。결과232례유선암중，Fas-670기인다태빈솔분포：순합야생형AA위39．7％（92/232）、잡합형AG위48．7％（113/232）、순합돌변형GG위11．6％（27/232）。Fas-670기인형여청해유선암림상병리지표무상관성（P＞0．05）。결론Fas-670기인다태성여청해지구유선암림상병리지표무련계。
Objective To investigate the correlation between Fas-670 gene polymorphisms and the clinic pathologic index of breast cancer in Qinghai district .Methods The polymorphisms of Fas-670 gene were detected by polymerase chain reaction-restric-tion fragment length polymorphisms assay (PCR-RFLP) in 232 female breast cancer patients ,χ2 test was applied to assess the asso-ciation between the polymorphisms of Fas-670 gene and breast cancer clinic pathologic index .Results In 232 breast cancer pa-tients ,the frequency of Fas-670 homozygous wild type(AA) ,heterozygous type(AG) ,homozygous mutant type(GG) were 39 .7%(92/232) ,48 .7% (113/232) ,11 .6% (27/232) respectively .It was no statistical significance between Fas-670 gene polymorphisms and the clinic pathologic index of breast cancer in Qinghai district(P>0 .05) .Conclusion The polymorphisms of Fas-670 gene is not associated with clinic pathologic index of breast cancer in Qinghai district .