CAJ | 학술논문

目的：研究谷胱甘肽S-转移酶M1（GSTM1）基因和谷胱甘肽S-转移酶P1（GSTP1）基因单核苷酸多态性（SNP）与非小细胞肺癌（NSCLC ）化疗敏感性的关系。方法分别应用基因测序法和 PCR法检测89例以铂类药物为主要化疗方案的NSCLC患者外周血GSTM1和GSTP1 DNA基因型，所有肺癌患者经过两周期含铂化疗后进行疗效评价，比较不同基因型与化疗疗效的关系。结果89例患者化疗总有效率为29．2％。 GSTP1 Ile105Val基因型和GSTM1基因型在化疗有效组和无效组之间差异无统计学意义（P＞0．05）。结论 GSTP1 Ile105Val基因型和GSTM1基因型SNP可能与NSCLC化疗耐受无关。
목적：연구곡광감태S-전이매M1（GSTM1）기인화곡광감태S-전이매P1（GSTP1）기인단핵감산다태성（SNP）여비소세포폐암（NSCLC ）화료민감성적관계。방법분별응용기인측서법화 PCR법검측89례이박류약물위주요화료방안적NSCLC환자외주혈GSTM1화GSTP1 DNA기인형，소유폐암환자경과량주기함박화료후진행료효평개，비교불동기인형여화료료효적관계。결과89례환자화료총유효솔위29．2％。 GSTP1 Ile105Val기인형화GSTM1기인형재화료유효조화무효조지간차이무통계학의의（P＞0．05）。결론 GSTP1 Ile105Val기인형화GSTM1기인형SNP가능여NSCLC화료내수무관。
Objective To investigate the relationship between glutathione S-transferases P1(GSTP1)Ile105Val and glutathione S-transferases M1(GSTM1)single nucleotide polymorphisms(SNP) and the sensitivity to chemotherapy among patients with ad-vanced non-small cell lung cancer(NSCLC) .Methods We used gene sequencing analysis to determine the SNP of GSTP1 Ile105Val and PCR analysis to GSTM1 in DNA from peripheral lymphocytes of NSCLC patients .Totally 89 patients with NSCLC were trea-ted with platinum-based chemotherapy ,and clinical response was evaluated after 2 cycles .The association between GSTP1 Ile105Val and GSTM1 SNP and chemosensitivity were analyzed .Results The overall response rate was 29 .2% .Chemotherapy re-sponse did not show statistically significant differences between the wild genotypes and the variant genotypes for the GSTP1 Ile105Val and GSTM1 gene(P>0 .05) .Conclusion The polymorphisms of GSTP1 Ile105Val and GSTM1 may be not associated with sensitivity to chemotherapy in NSCLC patients .