CAJ | 학술논문

目的：探讨血浆单核细胞水平及心功能指标与心房颤动（A F ）间的关系。方法2010年4月至2013年6月该院心内科A F住院患者298例为A F组，同期300例非A F患者为对照组，通过 t检验进行组间及亚组统计分析。结果 A F组血浆单核细胞、血浆氨基末端B型利钠肽前体（NT-proBNP）、左心房内径明显高于对照组（P＜0．05），左心室射血分数（LVEF）低于对照组（P＜0．05）。阵发性AF组NT-proBNP、左心房内径、LVEF与非阵发性AF组比较差异有统计学意义（P＜0．05）。心力衰竭合并心房颤动（HF＋AF）组与心力衰竭合并窦律（HF＋SR）组比较，前者在NT-proBNP和左心房内径上显著高于后者，LVEF低于后者，差异有统计学差异（P＜0．05）。结论单核细胞作为重要的炎症介质可能参与了AF的发生、发展。
목적：탐토혈장단핵세포수평급심공능지표여심방전동（A F ）간적관계。방법2010년4월지2013년6월해원심내과A F주원환자298례위A F조，동기300례비A F환자위대조조，통과 t검험진행조간급아조통계분석。결과 A F조혈장단핵세포、혈장안기말단B형리납태전체（NT-proBNP）、좌심방내경명현고우대조조（P＜0．05），좌심실사혈분수（LVEF）저우대조조（P＜0．05）。진발성AF조NT-proBNP、좌심방내경、LVEF여비진발성AF조비교차이유통계학의의（P＜0．05）。심력쇠갈합병심방전동（HF＋AF）조여심력쇠갈합병두률（HF＋SR）조비교，전자재NT-proBNP화좌심방내경상현저고우후자，LVEF저우후자，차이유통계학차이（P＜0．05）。결론단핵세포작위중요적염증개질가능삼여료AF적발생、발전。
Objective To analyze the relationship between atrial fibrillation (AF) and plasma mononuclear cells or cardiac func-tion .Methods From April 2010 to Jun 2013 ,298 patients with AF from department of cardiology in our hospital were selected as study group ,300 patients without AF were selected as control group in the same period .Both group and the subgroup were analy-sised by t test .Results Plasma monocyte NT-proBNP ,left atrial diameter in AF group were significantly higher than the control group(P<0 .05) ,LVEF was lower than the control group ,the statistical differences between the two groups (P<0 .05) .Compare HF combine AF with HF only ,the NT-proBNP and left atrial diameter were significantly higher in former and the LVEF is lower than the latter ,both with the difference statistical significantly (P< 0 .05) .Merge heart failure combined with atrial fibrillation (HF+AF) and heart failure combined sinus rhythm (HF+ SR) group ,the former in the NT-proBNP and left atrial diameterwere significantly higher than the latter ,LVEF lower than the latter ,the difference was statistically difference (P<0 .05) .Conclusion In the development of AF ,the monocytes may be involved in the occurrence and development of AF .