CAJ | 학술논문

目的：研究肝再生增强因子（ALR）在 HBV相关慢加急性肝功能衰竭（ACLF）中的水平变化及临床意义。方法病例来源于该科门诊及住院的慢性乙型肝炎患者，包括ACLF组（n＝214）和慢性乙型肝炎轻度组（n＝196）；对照组（n＝200）来源于输血科健康献血者。采用ELISA法检测各组对象血清ALR水平，分析ACLF组ALR水平与患者终末期肝病模型（MELD）评分关系。单因素非条件Logistic回归分析ALR水平与ACLF患者预后的相关性。结果 ACLF组ALR水平明显高于慢性乙型肝炎轻度组和对照组（P＜0．01）。ACLF患者ALR水平与MELD评分呈负相关（r2＝-0．249，F＝13．955，P＜0．01）。ACLF患者生存组ALR水平明显高于死亡组（P＝0．004）。单因素非条件Logistic回归分析表明ALR水平与ACLF患者24周预后相关，高水平ALR患者预后较好（P＝0．012，OR＝0．807）。结论 HBV相关 ACLF患者ALR水平明显升高，有利于肝细胞再生，可以作为评价患者预后指标。
목적：연구간재생증강인자（ALR）재 HBV상관만가급성간공능쇠갈（ACLF）중적수평변화급림상의의。방법병례래원우해과문진급주원적만성을형간염환자，포괄ACLF조（n＝214）화만성을형간염경도조（n＝196）；대조조（n＝200）래원우수혈과건강헌혈자。채용ELISA법검측각조대상혈청ALR수평，분석ACLF조ALR수평여환자종말기간병모형（MELD）평분관계。단인소비조건Logistic회귀분석ALR수평여ACLF환자예후적상관성。결과 ACLF조ALR수평명현고우만성을형간염경도조화대조조（P＜0．01）。ACLF환자ALR수평여MELD평분정부상관（r2＝-0．249，F＝13．955，P＜0．01）。ACLF환자생존조ALR수평명현고우사망조（P＝0．004）。단인소비조건Logistic회귀분석표명ALR수평여ACLF환자24주예후상관，고수평ALR환자예후교호（P＝0．012，OR＝0．807）。결론 HBV상관 ACLF환자ALR수평명현승고，유리우간세포재생，가이작위평개환자예후지표。
Objective To investigate the expression and clinical significance of augmenter of liver regeneration (ALR) in patients with HBV related acute on chronic liver failure (ACLF) .Methods The serum and clinical data of patients with ACLF (ACLF group ,n=214) ,patients with mild chronic hepatitis B (mild chronic hepatitis B group ,n=196) were collected from outpatient and inpatient in the hospital ,and control group(n=200) people were the blood transfusion healthy blood donors .The level of ALR was measured by ELISA method .The correlation between ALR and MELD score of patients with ACLF were analyzed by linear regres-sion analysis .Unconditioned binary response logistic regression model was used to determine the correlation between ALR and mor-tality at 24 weeks of patients with ACLF .Results Serum ALR level was higher in ACLF group than in mild chronic hepatitis B group and control group(P<0 .05) .There were negative correlations between the serum ALR level and MELD score of patients with ACLF(r2 = -0 .249 ,F=13 .955 ,P<0 .01) .Serum ALR level of patients with ACLF was more significant in survival group than in dead group(P=0 .004) .Logistic regression analysis identified that high serum ALR level was related to the good prognosis (P=0 .012 ,OR=0 .807) .Conclusion The serum ALR level was significantly increased in patients with HBV related ACLF which played an important role in liver regeneration and improve the prognosis of patients .