CAJ | 학술논문

目的：观察两种高效抗逆转录病毒治疗（HAART ）方案应用48周对 HIV/AIDS患者血脂的影响。方法将102例HIV/AIDS患者根据不同的 HAART方案分为司他夫定（D4T）组[D4T联合拉米夫定（3TC）及奈韦拉平（NVP）治疗]和齐多夫定（AZT ）组（AZT联合3TC及NVP治疗）。检测基线及HAART后24、48周时的三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）水平。结果配对 t检验分析，D4T组患者24周 TG、TC和LDL-C均显著升高（P＜0．05），48周TC仍持续升高（P＜0．05）；AZT组24周TC和TG显著升高（P＜0．05）。独立 t检验分析，24、48周两组间比较血脂各项指标差异无统计学意义（P＞0．05）。结论包含D4T 和AZT 的 HAART 方案均可导致 HIV/AIDS患者血脂异常，主要是TG和TC升高，均以边缘升高为主。应用包含D4T的方案的 HIV/AIDS患者TG和TC升高较早，并且TC升高后持续保持在较高的水平。
목적：관찰량충고효항역전록병독치료（HAART ）방안응용48주대 HIV/AIDS환자혈지적영향。방법장102례HIV/AIDS환자근거불동적 HAART방안분위사타부정（D4T）조[D4T연합랍미부정（3TC）급내위랍평（NVP）치료]화제다부정（AZT ）조（AZT연합3TC급NVP치료）。검측기선급HAART후24、48주시적삼선감유（TG）、총담고순（TC）、저밀도지단백담고순（LDL-C）、고밀도지단백담고순（HDL-C）수평。결과배대 t검험분석，D4T조환자24주 TG、TC화LDL-C균현저승고（P＜0．05），48주TC잉지속승고（P＜0．05）；AZT조24주TC화TG현저승고（P＜0．05）。독립 t검험분석，24、48주량조간비교혈지각항지표차이무통계학의의（P＞0．05）。결론포함D4T 화AZT 적 HAART 방안균가도치 HIV/AIDS환자혈지이상，주요시TG화TC승고，균이변연승고위주。응용포함D4T적방안적 HIV/AIDS환자TG화TC승고교조，병차TC승고후지속보지재교고적수평。
Objective To understand the impact to blood lipid in patients with HIV/AIDS using different HAART regimens . Methods According to HAART regimens ,102 HIV/AIDS patients were divided into two groups :D4T group(D4T+3TC+NVP) and AZT group(AZT+3TC+ NVP) .Blood lipids(TG ,TC ,LDL-C and HDL-C)at baseline ,24 weeks and 48 weeks after HAART were detected .Results Compared with paired t test ,TG ,TC and LDL-C at 24 weeks follow-up of the patients in D4T group were significantly higher than at baseline(P<0 .05) ,and TC at 48 weeks follow-up were still higher than at baseline(P<0 .05) .TG and TC at 24 weeks follow-up of patients in AZT group were significantly higher than at baseline(P<0 .05) .There were no significant difference at blood lipid between the two groups(P>0 .05) .Conclusion There are dyslipidemia of the patients with HIV/AIDS u-sing D4T-based and AZT-based regimens ,and the dyslipidemia are increase of TC and TG ,these increase is border higher .TG and TC at 24 weeks follow-up of the HIV/AIDS patients using D4T-based regimen are increased early ,and TC are still at higher level .