CAJ | 학술논문

目的：探究老年有机磷中毒重度型应用血浆置换联合血液灌流疗法的临床效果。方法有机磷中毒老年患者100例，按治疗方式的不同分为对照组和治疗组，每组50例。对照组进行血液灌流疗法，治疗组进行血液灌流联合血浆置换疗法，观察两组患者各项生化指标、临床疗效和并发症的情况。结果两组治疗后各项生化指标均有改善，但治疗组的指标水平明显优于对照组；治疗组的阿托品中毒、中间综合征、病死和反跳等并发症的发生率显著低于对照组，差异具有统计学意义(P<0.05)。结论血液灌流联合血浆置换抢救老年重度有机磷中毒，有效的减少了患者并发症的发生，降低了患者各项生化指标的数值，提高了患者预后的生活水平，值得在临床上推广。
목적：탐구노년유궤린중독중도형응용혈장치환연합혈액관류요법적림상효과。방법유궤린중독노년환자100례，안치료방식적불동분위대조조화치료조，매조50례。대조조진행혈액관류요법，치료조진행혈액관류연합혈장치환요법，관찰량조환자각항생화지표、림상료효화병발증적정황。결과량조치료후각항생화지표균유개선，단치료조적지표수평명현우우대조조；치료조적아탁품중독、중간종합정、병사화반도등병발증적발생솔현저저우대조조，차이구유통계학의의(P<0.05)。결론혈액관류연합혈장치환창구노년중도유궤린중독，유효적감소료환자병발증적발생，강저료환자각항생화지표적수치，제고료환자예후적생활수평，치득재림상상추엄。
ObjectiveTo discuss the clinical effect of combination of hemoperfusion and plasmapheresis in the treatment of elderly patients with severe organophosphate poisoning.MethodsDivided 100 elderly patients with severe organophosphate poisoning into control group and treatment group according to different treatment methods, each with 50 cases. Control group was given hemoperfusion therapy while treatment group was given combined therapy of hemoperfusion and plasmapheresis. Biochemical indicators, clinical effects and complications of two groups were observed.ResultsBiochemical indicators of both groups improved after treatment, but indicator levels of treatment group were obviously higher than control group; occurrence rates of atropinismus, intermediate syndrome, fatality and rebound were obviously lower than control group(P<0.05). ConclusionCombination of hemoperfusion and plasmapheresis for rescue of elderly patients with severe organophosphate poisoning effectively reduces occurrences of complications, decreases values of biochemical indicators and improves prognostic life levels of patients, so it is worthy of clinical promotion.