CAJ | 학술논문

目的：探讨黄芪注射液治疗ICU老年重症患者肺部感染的效果。方法选取2013年5月~2014年3月广东省人民医院ICU收治的老年重症患者50例，均伴有肺部感染，按双盲随机原则分为对照组和黄芪组，各25例。两组入院后均给予常规综合治疗，包括控制肺部感染、祛痰、支气管扩张剂、皮质激素、给氧、利尿等。黄芪组在常规治疗基础上给予黄芪注射液治疗。比较两组患者的临床疗效、症状、体征消失及住院时间、病情积分。结果黄芪组治疗总有效率为92%，明显高于对照组(76%)，两组比较，差异有统计学意义(P<0.05)。黄芪组治疗后患者发热持续时间[(4.36依1.25)d]、咳嗽持续时间[(6.53依2.33)d]、肺部体征持续时间[(7.12依2.13)d]、X线阴影消失时间[(11.16依3.11)d]、住院时间[(11.84依2.27)均明显短于对照组，差异有统计学意义(P<0.05)。治疗前两组患者病情积分比较差异无统计学意义(P>0.05)，治疗后，黄芪组患者的病情积分[发热院(0.35依0.11)分，咳嗽院(0.52依0.14)分，咳痰院(0.86依0.25)分，气喘院(0.18依0.09)分，血象院(0.42依0.11)分，痰培养院(0.36依0.12)分，总分院(3.14依1.11)分]明显低于对照组[发热院(0.79依0.23)分，咳嗽院(1.21依0.35)分，咳痰院(1.18依0.31)分，气喘院(0.32依0.11)分，血象院(0.51依0.23)分，痰培养院(0.45依0.16)分，总分院(6.79依1.39)分]，差异有统计学意义(P<0.05)。结论黄芪注射液治疗ICU老年重症患者肺部感染效果较好，能减少并发症，值得临床推广应用。
목적：탐토황기주사액치료ICU노년중증환자폐부감염적효과。방법선취2013년5월~2014년3월광동성인민의원ICU수치적노년중증환자50례，균반유폐부감염，안쌍맹수궤원칙분위대조조화황기조，각25례。량조입원후균급여상규종합치료，포괄공제폐부감염、거담、지기관확장제、피질격소、급양、이뇨등。황기조재상규치료기출상급여황기주사액치료。비교량조환자적림상료효、증상、체정소실급주원시간、병정적분。결과황기조치료총유효솔위92%，명현고우대조조(76%)，량조비교，차이유통계학의의(P<0.05)。황기조치료후환자발열지속시간[(4.36의1.25)d]、해수지속시간[(6.53의2.33)d]、폐부체정지속시간[(7.12의2.13)d]、X선음영소실시간[(11.16의3.11)d]、주원시간[(11.84의2.27)균명현단우대조조，차이유통계학의의(P<0.05)。치료전량조환자병정적분비교차이무통계학의의(P>0.05)，치료후，황기조환자적병정적분[발열원(0.35의0.11)분，해수원(0.52의0.14)분，해담원(0.86의0.25)분，기천원(0.18의0.09)분，혈상원(0.42의0.11)분，담배양원(0.36의0.12)분，총분원(3.14의1.11)분]명현저우대조조[발열원(0.79의0.23)분，해수원(1.21의0.35)분，해담원(1.18의0.31)분，기천원(0.32의0.11)분，혈상원(0.51의0.23)분，담배양원(0.45의0.16)분，총분원(6.79의1.39)분]，차이유통계학의의(P<0.05)。결론황기주사액치료ICU노년중증환자폐부감염효과교호，능감소병발증，치득림상추엄응용。
Objective To explore the effect of Astragalus Injection in the treatment of ICU elderly critical patients with lung infection. Methods 50 elderly critical patients in ICU of Guangdong Provincial People's Hospital from May 2013 to March 2014 were collected. All patients suffered with lung infection and divided into control group and Astragalus group according to double-blind randomized method, each group had 25 patients. Patients in the two groups were all given routine comprehensive treatment, including control of pulmonary infection, expectorant, bronchodilators, corticos-teroids, give oxygen, diuresis. On the basis of the control group, patients in the Astragalus group were given Astragalus Injection treatment. The clinical efficacy, symptoms and signs disappearance time, hospitalization time, illness score of the two groups were all compared. Results The total effective rate in Astragalus group was 92%, which was significant-ly higher than that in control group (76%), the difference was statistically significant (P < 0.05). In the Astragalus group, after treatment duration of fever [(4.36±1.25) d], cough duration [(6.53±2.33) d], lungs symptom duration [(7.12±2.13) d], X ray shadow disappearance time [(11.16 ±3.11) d], hospital stays [(11.84±2.27) d] were significantly shorter than those in the control group, the differences were statistically significant (P< 0.05). The illness integrals were com-pared before treatment between the two groups, the differences were not statistically significant (P> 0.05). After treat-ment, the illness integrals [fever:(0.35±0.11) scores, cough:(0.52±0.14) scores, expectoration:(0.86±0.25) scores, asthma:(0.18±0.09) scores, hemogram:(0.42±0.11) scores, sputum culture:(0.36±0.12) scores, total points:(3.14±1.11) scores] in the Astragalus group were lower than those in the control group[fever:(0.79±0.23) scores, cough:(1.21±0.35) scores, expectoration:(1.18±0.31) scores, asthma:(0.32±0.11)scores, hemogram:(0.51±0.23) scores, sputum culture:(0.45±0.16) scores, total points:(6.79±1.39) scores], the differences were statistically significant (P<0.05). Conclusion Astragalus injection in the treatment of ICU elderly critical patients with lung infection has good effect, which can significantly reduce the lung infection, reduce complications, which is worthy of clinical application.