CAJ | 학술논문

目的：探讨口服爱维治治疗急性放射性食管炎的可行性，比较口服用药与腹腔用药治疗急性放射性食管炎的疗效。方法将30只13周龄的雄性C57小鼠单次照射上段食管30 Gy后，随机分为1组（对照组）、2组（口服组）和3组（腹腔注射组）。记录每周小鼠体质量变化，于第1周、第2周和第4周分批处死小鼠，取食管组织进行 HE染色及TGF-β免疫组化染色。比较3组体质量变化情况、黏膜损伤分级和TGF-β染色分级。结果食管黏膜损伤2、3组比较差异无统计学意义（P＝0．318），但是均好于对照组（P＜0．05）。腹腔注射小鼠实验期间体质量较对照组有改善（P＝0．030）。结论口服爱维治可以减轻食管黏膜组织损伤，一定程度上减轻了食管炎症状，腹腔应用爱维治可以改善急性放射性食管炎小鼠营养状况。
목적：탐토구복애유치치료급성방사성식관염적가행성，비교구복용약여복강용약치료급성방사성식관염적료효。방법장30지13주령적웅성C57소서단차조사상단식관30 Gy후，수궤분위1조（대조조）、2조（구복조）화3조（복강주사조）。기록매주소서체질량변화，우제1주、제2주화제4주분비처사소서，취식관조직진행 HE염색급TGF-β면역조화염색。비교3조체질량변화정황、점막손상분급화TGF-β염색분급。결과식관점막손상2、3조비교차이무통계학의의（P＝0．318），단시균호우대조조（P＜0．05）。복강주사소서실험기간체질량교대조조유개선（P＝0．030）。결론구복애유치가이감경식관점막조직손상，일정정도상감경료식관염증상，복강응용애유치가이개선급성방사성식관염소서영양상황。
Objective To evaluate the feasibility and effect of taking Actovegin orally in cureing acute radiation esophagitis ,and to compare the curative effect of oral drugs and abdominal cavity medicine .Methods Thirty male mouses were randomly divided in-to three groups after upper moiety esophageal radiation :the control group(irradiation only) ,the oral group(take Actovegin orally) , and the celiac injection group .The weight chang was tracked record weekly ,and the mouses were killed in batches at the seventh day ,the fourteenth day ,and the twenty eighth day .The grade about esophageal breakage ,inflammation and immunochemical colour-ation by TGF-βwere analysed .Results Esophageal breakage in the oral group and the celiac injection group had not significantly deffrence (P=0 .318) ,but they had better than the control group(P<0 .05);The celiac injection group had less weight decrease than the control group(P=0 .030) .Conclusion The mouses′cacotrophia with acute radiation esophagitis can be improved by Acto-vegin mainline .Taking Actovegin orally can reduce esophageal damnification .