CAJ | 학술논문

目的：比较吸入性糖皮质激素与孟鲁司特或吸入性糖皮质激素联合孟鲁司特与吸入性糖皮质激素治疗儿童轻中度哮喘的疗效。方法检索Pubmed、Embase、Central databases、CNKI、VIP等数据库自建库至今的关于吸入性糖皮质激素与孟鲁司特治疗儿童哮喘的随机对照试验（RCT ），对纳入研究根据Cochrane协作网推荐的风险偏倚工具进行文献质量评价。结果接受吸入性糖皮质激素治疗的患者的一秒用力呼气容积（FEV1）变化量占预计值百分比、呼气峰流量（PEF）的改善均优于接受孟鲁司特治疗的患者，两种治疗方法药物不良反应事件发生率无差异。接受吸入性糖皮质激素联合孟鲁司特治疗的患者FEV1、PEF的改善明显优于接受吸入性糖皮质激素治疗的患者。结论吸入性糖皮质激素的治疗效果优于孟鲁司特，吸入性糖皮质激素联合孟鲁司特的治疗效果优于单纯吸入性糖皮质激素治疗，且药物安全性较好。
목적：비교흡입성당피질격소여맹로사특혹흡입성당피질격소연합맹로사특여흡입성당피질격소치료인동경중도효천적료효。방법검색Pubmed、Embase、Central databases、CNKI、VIP등수거고자건고지금적관우흡입성당피질격소여맹로사특치료인동효천적수궤대조시험（RCT ），대납입연구근거Cochrane협작망추천적풍험편의공구진행문헌질량평개。결과접수흡입성당피질격소치료적환자적일초용력호기용적（FEV1）변화량점예계치백분비、호기봉류량（PEF）적개선균우우접수맹로사특치료적환자，량충치료방법약물불량반응사건발생솔무차이。접수흡입성당피질격소연합맹로사특치료적환자FEV1、PEF적개선명현우우접수흡입성당피질격소치료적환자。결론흡입성당피질격소적치료효과우우맹로사특，흡입성당피질격소연합맹로사특적치료효과우우단순흡입성당피질격소치료，차약물안전성교호。
Objective To compare the effect of inhaled corticosteroids and montelukast in children with asthma .Methods Data were obtained from Pubmed ,Embase and Central databases ,CNKI and VIP .Only randomized controlled trials (RCT ) that evalua-ting inhaled corticosteroids and montelukast for children were included .The Cochrane collaboration risk bias tools was used to eval-uated the quality of literature .Results The patients with inhaled corticosteroids had a better effect in FEV 1% and PEF than pa-tients with montelukast ,the incidences of adverse drug reactions had no statistically significant difference .The patients with inhaled corticosteroids combined with montelukast had a better effect in FEV 1% or PEF than patients with inhaled corticosteroids only . Conclusion The effect of inhaled corticosteroids is better than montelukast ,the effect of inhaled corticosteroids combined with montelukast is better than inhaled corticosteroids only ,and has drug safety .