CAJ | 학술논문

目的：探讨预防性给予小剂量艾司西酞普兰对帕金森患者抑郁症状及整体症状的临床治疗效果。方法将40例患者随机分成吡贝地尔单用药组和吡贝地尔联合艾司西酞普兰联合用药组，每组20例。测量患者Hamilton抑郁量表（HAMD）、帕金森综合评分量表（UPDRS）及39项帕金森调查问卷（PDQ-39）评分，评定患者抑郁的改变和帕金森整体症状的改变。结果治疗后2周与治疗前比较，单用药组 HAMD评分差异无统计学意义（P＞0．05），联合用药组显著下降（P＜0．05）；两组UPDRS评分及PDQ-39评分明显下降（P＜0．05），比较差异无统计学意义（P＞0．05）。治疗后6周，两组 HAMD 评分、UPDRS评分及PDQ-39评分较治疗前明显降低（P＜0．05），两组间差异有统计学意义（P＜0．05）。结论预防性给予小剂量艾司西酞普兰可早期控制帕金森患者轻微抑郁症状，也可以改善帕金森患者整体症状，探索性地为临床治疗帕金森疾病提出新思路。
목적：탐토예방성급여소제량애사서태보란대파금삼환자억욱증상급정체증상적림상치료효과。방법장40례환자수궤분성필패지이단용약조화필패지이연합애사서태보란연합용약조，매조20례。측량환자Hamilton억욱량표（HAMD）、파금삼종합평분량표（UPDRS）급39항파금삼조사문권（PDQ-39）평분，평정환자억욱적개변화파금삼정체증상적개변。결과치료후2주여치료전비교，단용약조 HAMD평분차이무통계학의의（P＞0．05），연합용약조현저하강（P＜0．05）；량조UPDRS평분급PDQ-39평분명현하강（P＜0．05），비교차이무통계학의의（P＞0．05）。치료후6주，량조 HAMD 평분、UPDRS평분급PDQ-39평분교치료전명현강저（P＜0．05），량조간차이유통계학의의（P＜0．05）。결론예방성급여소제량애사서태보란가조기공제파금삼환자경미억욱증상，야가이개선파금삼환자정체증상，탐색성지위림상치료파금삼질병제출신사로。
Objective To investigate the clinical effect of prophylactic low dose of escitalopram in patients with depressive symp-toms and overall symptoms of Parkinson′s .Methods 40 patients were divided into single drug group used alone Piribedil and com-bined treatment group used Piribedil and escitalopram ,20 cases in each group .Hamilton depression scale (HAMD) ,Parkinson′s disease questionnaire composite score standard (UPDRS) and 39 Parkinson′s disease questionnaire score (PDQ-39) prior treatment were used to assess the changes of the patients′degree of depression and the Parkinson′s overall symptoms .Results Compared with prior treatment ,the HAMD score in single drug group after two weeks treatment had no significant difference (P> 0 .05) , while in combined treatment group ,the HAMD score decreased significantly (P<0 .05) .Compared with prior treatment ,both in single drug group and the combined treatment group ,the UPDRS scores and PDQ-39 rating decreased significantly (P<0 .05) ,but without significant difference between the two groups(P>0 .05) .After six weeks treatment ,Compared with prior treatment ,both in single drug group and combined treatment group ,the HAMD score ,UPDRS score and PDQ-39 score had significantly decreased (P<0 .05) ,but without significant differences between the two groups (P<0 .05) .Conclusion Prophylactic low dose of escitalo-pram may be early control of symptoms of Parkinson′s patients with mild depression .It can also be used to improve the overall symptoms of Parkinson′s patients ,which propose new ideas for the clinical treatment of Parkinson′s disease .