中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
22期
3-4
,共2页
苯海拉明软膏%盐酸苯海拉明%容量分析法%含量测定
苯海拉明軟膏%鹽痠苯海拉明%容量分析法%含量測定
분해랍명연고%염산분해랍명%용량분석법%함량측정
Diphenhydramine ointment%Diphenhydramine hydrochloride%Volumetric method%Content determination
目的：建立苯海拉明软膏中盐酸苯海拉明的含量测定方法。方法比较铬酸钾指示剂法和酸碱滴定法的线性、精密度和回收率。结果铬酸钾指示剂法中，盐酸苯海拉明在3.99~19.94 mg/ml范围内有良好的线性关系， r=0.9999；平均回收率为97.15%， RSD为1.59%。酸碱滴定法中盐酸苯海拉明在4.06~20.32 mg/ml范围呈现良好的线性关系， r=0.9993；平均回收率为98.90%， RSD=0.84%。结论酸碱滴定法准确、可靠，可用于苯海拉明软膏中盐酸苯海拉明的含量测定。
目的：建立苯海拉明軟膏中鹽痠苯海拉明的含量測定方法。方法比較鉻痠鉀指示劑法和痠堿滴定法的線性、精密度和迴收率。結果鉻痠鉀指示劑法中，鹽痠苯海拉明在3.99~19.94 mg/ml範圍內有良好的線性關繫， r=0.9999；平均迴收率為97.15%， RSD為1.59%。痠堿滴定法中鹽痠苯海拉明在4.06~20.32 mg/ml範圍呈現良好的線性關繫， r=0.9993；平均迴收率為98.90%， RSD=0.84%。結論痠堿滴定法準確、可靠，可用于苯海拉明軟膏中鹽痠苯海拉明的含量測定。
목적：건립분해랍명연고중염산분해랍명적함량측정방법。방법비교락산갑지시제법화산감적정법적선성、정밀도화회수솔。결과락산갑지시제법중，염산분해랍명재3.99~19.94 mg/ml범위내유량호적선성관계， r=0.9999；평균회수솔위97.15%， RSD위1.59%。산감적정법중염산분해랍명재4.06~20.32 mg/ml범위정현량호적선성관계， r=0.9993；평균회수솔위98.90%， RSD=0.84%。결론산감적정법준학、가고，가용우분해랍명연고중염산분해랍명적함량측정。
Objective To establish a method to determine the contents of diphenhydramine hydrochloride in diphenhydramine ointment. Methods Linearity, precision and recovery between potassium chromate indicator method and acid-base titration method were compared. Results By potassium chromate indicator method, diphenhydramine hydrochloride yielded a linear range of 3.99~19.94 mg/ml (r=0.9999), with the average recovery of 97.15%and RSD of 1.59%. By acid-base titration, determination of diphenhydramine hydrochloride yielded a linear range of 4.06~20.32 mg/ml (r=0.9993), with the average recovery of 98.90%and RSD of 0.84%. Conclusion Acid-base titration method is accurate, reliable, and can be used for content determination of diphenhydramine hydrochloride in diphenhydramine ointment.
