CAJ | 학술논문

目的：检测抗环瓜氨酸肽抗体(抗CCP抗体)在类风湿性关节炎(RA)诊断中的敏感性和特异性，研究评价抗CCP抗体检测在RA早期诊断中的临床意义。方法：采用酶联免疫吸附法(ELISA)检测338例血清标本抗CCP抗体以及 RFIg-A、RFIg-G、RFIg-M。结果：抗 CCP 抗体特异性高达94.8%，敏感性94.5%；RF 敏感性97.2%，特异性71.6%。结论：抗CCP抗体对RA诊断的特异性很高，联合RF的检测能明显提高RA早期诊断的准确性。
목적：검측항배과안산태항체(항CCP항체)재류풍습성관절염(RA)진단중적민감성화특이성，연구평개항CCP항체검측재RA조기진단중적림상의의。방법：채용매련면역흡부법(ELISA)검측338례혈청표본항CCP항체이급 RFIg-A、RFIg-G、RFIg-M。결과：항 CCP 항체특이성고체94.8%，민감성94.5%；RF 민감성97.2%，특이성71.6%。결론：항CCP항체대RA진단적특이성흔고，연합RF적검측능명현제고RA조기진단적준학성。
Objective:To detect the sensitivity and specificity of anti-cyclic citrullinated peptide antibody(anti CCP antibody) in the diagnosis of early rheumatoid arthritis,and to study and evaluate the clinical significance of anti CCP antibody detection in the diagnosis of early RA.Methods:In 338 cases of serum specimens,anti CCP antibody and RFIg-A、 RFIg-G、 RFIg-M were detected by enzyme linked immunosorbent assay(ELISA).Results:The specificity of anti CCP antibody was as high as 94.8%;the sensitivity was 94.5%.The sensitivity of RF was 97.2%;the specificity was 71.6%.Conclusion:Anti CCP antibody has a very high diagnostic specificity for RA.Detection combined with RF can improve the accuracy of RA early diagnosis.