中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
22期
30-31
,共2页
高血压%替米沙坦%血压变化%昼夜节律%不良反应
高血壓%替米沙坦%血壓變化%晝夜節律%不良反應
고혈압%체미사탄%혈압변화%주야절률%불량반응
Hypertension%Telmisartan%Blood pressure change%Circadian rhythm%Adverse reaction
目的：研究分析替米沙坦治疗不同类型高血压的不同用药方案及其治疗效果，为其临床应用和研究提供有效的理论支撑。方法：2012年10月-2013年12月收治非杓型轻中度原发性高血压患者200例。根据患者在院接受治疗的不同时间，随机分为对照组和治疗组，各100例。对照组于上午8时行替米沙坦治疗，治疗组于晚8时行替米沙坦治疗，用药剂量均80 mg/次，1次/日，治疗12周后比较两组治疗效果。结果：与对照组相比，治疗组24小时无创动态血压监测情况及治疗后的收缩压与舒张压水平均明显改善，差异具有统计学意义(P＜0.05)；与对照组相比，治疗组不良反应发生情况较少，差异具有统计学意义(P＜0.05)。结论：非杓型原发性高血压患者经替米沙坦治疗，于晚8时用药效果更佳，可有效的改善患者的血压类型，促进昼夜节律的恢复。
目的：研究分析替米沙坦治療不同類型高血壓的不同用藥方案及其治療效果，為其臨床應用和研究提供有效的理論支撐。方法：2012年10月-2013年12月收治非杓型輕中度原髮性高血壓患者200例。根據患者在院接受治療的不同時間，隨機分為對照組和治療組，各100例。對照組于上午8時行替米沙坦治療，治療組于晚8時行替米沙坦治療，用藥劑量均80 mg/次，1次/日，治療12週後比較兩組治療效果。結果：與對照組相比，治療組24小時無創動態血壓鑑測情況及治療後的收縮壓與舒張壓水平均明顯改善，差異具有統計學意義(P＜0.05)；與對照組相比，治療組不良反應髮生情況較少，差異具有統計學意義(P＜0.05)。結論：非杓型原髮性高血壓患者經替米沙坦治療，于晚8時用藥效果更佳，可有效的改善患者的血壓類型，促進晝夜節律的恢複。
목적：연구분석체미사탄치료불동류형고혈압적불동용약방안급기치료효과，위기림상응용화연구제공유효적이론지탱。방법：2012년10월-2013년12월수치비표형경중도원발성고혈압환자200례。근거환자재원접수치료적불동시간，수궤분위대조조화치료조，각100례。대조조우상오8시행체미사탄치료，치료조우만8시행체미사탄치료，용약제량균80 mg/차，1차/일，치료12주후비교량조치료효과。결과：여대조조상비，치료조24소시무창동태혈압감측정황급치료후적수축압여서장압수평균명현개선，차이구유통계학의의(P＜0.05)；여대조조상비，치료조불량반응발생정황교소，차이구유통계학의의(P＜0.05)。결론：비표형원발성고혈압환자경체미사탄치료，우만8시용약효과경가，가유효적개선환자적혈압류형，촉진주야절률적회복。
Objective:To study and analyze the different dosage regimen and treatment effect of telmisartan in the treatment of different types of hypertension.To provide a theoretical support for the clinical application and research.Methods:200 cases with non dipper mild-to-moderate essential hypertension were selected from October 2012 to December 2013.According to the different times of patients receiving treatment in hospital,they were randomly divided into the treatment group and the control group with 100 cases in each.The control group were treated with telmisartan at eight in the morning.The treatment group were treated with telmisartan at eight in the evening.The medication doses were 80 mg one time,1 time one day.After 12 weeks treatment,the treatment effects were compared between the two groups.Results:Compared with the control group,the 24 hours noninvasive ambulatory blood pressure monitoring condition and systolic blood pressure and diastolic blood pressure levels after treatment of the treatment group were obviously improved,and the difference was statistically significant(P<0.05).Compared with the control group,the adverse reaction of the treatment group was less,and the difference was statistically significant(P<0.05). Conclusion: The medication effect of telmisartan for the patients with non dipper mild-to-moderate essential hypertension at night in the evening is better.It can effectively improve the patient's blood pressure type,and promote the recovery of circadian rhythm.
