中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
29期
4706-4711
,共6页
组织构建%骨组织工程%植入物%骨植入物%活血补肾中药%股骨头坏死%植骨
組織構建%骨組織工程%植入物%骨植入物%活血補腎中藥%股骨頭壞死%植骨
조직구건%골조직공정%식입물%골식입물%활혈보신중약%고골두배사%식골
drugs,Chinese herbal%femur head necrosis%bone transplantation%pain%range of motion,articular
背景：股骨头坏死保头治疗的关键在于重建并改善股骨头内的血运，保留股骨头的完整性，恢复股骨头的力学环境和血供，中药具有整体优势。高位头颈开窗支撑植骨能够恢复股骨头内的力学环境。
<br> 目的：观察活血补肾中药联合高位头颈开窗植骨支撑治疗非创伤性股骨头坏死的临床疗效。
<br> 方法：采用前瞻对比试验设计方案，将非创伤性股骨头坏死患者分为两组：治疗组52例60髋口服活血补肾方联合高位头颈开窗植骨支撑治疗，自拟活血补肾方由临沂市人民医院股骨头专科自制；对照组51例60髋单纯采用高位头颈开窗植骨支撑治疗。随访12个月，从末次随访髋关节功能Harris评分及其优良率两方面对疗效进行评价。
<br> 结果与结论：治疗组患者Harris总分、疼痛程度、关节活动范围分值均显著高于对照组(P <0.01)；两组关节畸形、功能分值差异无显著性意义(P>0.05)；治疗组患者疗效优良率显著高于对照组(88%，74%，χ2=4.54， P <0.05)。提示活血补肾中药联合高位头颈开窗植骨支撑治疗非创伤性股骨头坏死疗效肯定，在缓解或减轻疼痛、改善髋关节活动范围等方面优于单纯高位头颈开窗植骨支撑治疗。
揹景：股骨頭壞死保頭治療的關鍵在于重建併改善股骨頭內的血運，保留股骨頭的完整性，恢複股骨頭的力學環境和血供，中藥具有整體優勢。高位頭頸開窗支撐植骨能夠恢複股骨頭內的力學環境。
<br> 目的：觀察活血補腎中藥聯閤高位頭頸開窗植骨支撐治療非創傷性股骨頭壞死的臨床療效。
<br> 方法：採用前瞻對比試驗設計方案，將非創傷性股骨頭壞死患者分為兩組：治療組52例60髖口服活血補腎方聯閤高位頭頸開窗植骨支撐治療，自擬活血補腎方由臨沂市人民醫院股骨頭專科自製；對照組51例60髖單純採用高位頭頸開窗植骨支撐治療。隨訪12箇月，從末次隨訪髖關節功能Harris評分及其優良率兩方麵對療效進行評價。
<br> 結果與結論：治療組患者Harris總分、疼痛程度、關節活動範圍分值均顯著高于對照組(P <0.01)；兩組關節畸形、功能分值差異無顯著性意義(P>0.05)；治療組患者療效優良率顯著高于對照組(88%，74%，χ2=4.54， P <0.05)。提示活血補腎中藥聯閤高位頭頸開窗植骨支撐治療非創傷性股骨頭壞死療效肯定，在緩解或減輕疼痛、改善髖關節活動範圍等方麵優于單純高位頭頸開窗植骨支撐治療。
배경：고골두배사보두치료적관건재우중건병개선고골두내적혈운，보류고골두적완정성，회복고골두적역학배경화혈공，중약구유정체우세。고위두경개창지탱식골능구회복고골두내적역학배경。
<br> 목적：관찰활혈보신중약연합고위두경개창식골지탱치료비창상성고골두배사적림상료효。
<br> 방법：채용전첨대비시험설계방안，장비창상성고골두배사환자분위량조：치료조52례60관구복활혈보신방연합고위두경개창식골지탱치료，자의활혈보신방유림기시인민의원고골두전과자제；대조조51례60관단순채용고위두경개창식골지탱치료。수방12개월，종말차수방관관절공능Harris평분급기우량솔량방면대료효진행평개。
<br> 결과여결론：치료조환자Harris총분、동통정도、관절활동범위분치균현저고우대조조(P <0.01)；량조관절기형、공능분치차이무현저성의의(P>0.05)；치료조환자료효우량솔현저고우대조조(88%，74%，χ2=4.54， P <0.05)。제시활혈보신중약연합고위두경개창식골지탱치료비창상성고골두배사료효긍정，재완해혹감경동통、개선관관절활동범위등방면우우단순고위두경개창식골지탱치료。
BACKGROUND:The treatment of osteoporosis of the femoral head relies on the reconstruction and improvement of blood supply in the femoral head, maintenance of femoral head structure, restoration of mechanical environment and blood supply in femoral head. Traditional Chinese medicine treatment is very advantageous. Bone impaction grafting through a femoral neck window at high location can restore the mechanical environment in femoral head.
<br> OBJECTIVE:To investigate clinical efficacy of combined treatment of HUOXUEBUSHEN decoction and bone impaction grafting through a femoral neck window at high location for non-traumatic osteoporosis of the femoral head.
<br> METHODS:This study is a prospective control ed trial. The patients with non-traumatic osteoporosis of the femoral head were divided into two groups:treatment group (n=52, 60 hips) and control group (n=51, 60 hips). The treatment group was given a combined treatment of HUOXUEBUSHEN decoction and bone impaction grafting through a femoral neck window (the decoction was prepared in People’s Hospital of Linyi, China). The control group underwent simple bone impaction grafting through a femoral neck window. Al the involved patients were fol owed up for 12 months, Harris hip score and the excellent-good rate at the last fol ow-up were used to evaluate clinical efficacy.
<br> RESULTS AND CONCLUSION:The Harris score, pain degree, and joint range of motion scores in the treatment group were higher than that in control group (P<0.01), but joint deformities and functional scores showed no significant differences between two groups (P>0.05). The excellent-good rate in the treatment group was significantly higher than that in control group (88%, 75%;χ2=4.91, P<0.05). The combined treatment of HUOXUEBUSHEN decoction and bone impaction grafting through a femoral neck window at high location is effective in the treatment of non-traumatic osteonecrosis of the femoral head, and is better than simple bone impaction grafting at al eviating pain and improving joint range of motion.
